SCHEMBL3385240

SCHEMBL3385240

CCCCNCCC[Si](Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.45
DRD2 P14416 10/20 0.44
DRD4 P21917 10/20 0.44
DRD3 P35462 8/20 0.44
KMT2A Q03164 2/20 0.44
GAA P10253 2/20 0.41
MAPT P10636 2/20 0.41
HTT P42858 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
ALDH1A1 P00352 1/20 0.41
LTA4H P09960 1/20 0.40
KDM4E B2RXH2 1/20 0.39
ALOX12 P18054 1/20 0.39
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
HDAC3 O15379 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3383380 0.92 DRD2 (0.42) SIGMAR1DRD2DRD4DRD3KMT2A
SCHEMBL3386839 0.92 DRD2 (0.42) SIGMAR1DRD2DRD4DRD3KMT2A
SCHEMBL3353015 0.88 HTT (0.42) DRD2DRD4DRD3KMT2AHTT
SCHEMBL428858 0.86 LTA4H (0.47) DRD2DRD3KMT2AGAAMAPT
SCHEMBL2400834 0.84 LTA4H (0.47) DRD2DRD3KMT2AGAAMAPT
SCHEMBL958899 0.82 LTA4H (0.46) DRD2DRD3HTTALDH1A1LTA4H
SCHEMBL4810179 0.82 LTA4H (0.46) DRD2DRD3HTTALDH1A1LTA4H
SCHEMBL31187730 0.82 LTA4H (0.46) DRD2DRD3HTTALDH1A1LTA4H
SCHEMBL3354992 0.81 DRD2 (0.40) DRD2DRD4DRD3HTT
SCHEMBL3350037 0.81 DRD2 (0.40) DRD2DRD4DRD3HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100010166-A1 SILANE-TERMINATED PREPOLYMERS AND RELATIVE ADHESIVE SEALANT FORMULATIONS N.P.T. S.R.L. (IT) 2010-01-14 US disclosed
EP-2064256-A1 SILANE-TERMINATED PREPOLYMERS AND RELATIVE ADHESIVE SEALANT FORMULATIONS N.P.T. S.R.L. (IT) 2009-06-03 EP disclosed
WO-2008031895-A1 SILANE-TERMINATED PREPOLYMERS AND RELATIVE ADHESIVE SEALANT FORMULATIONS N.P.T. S.R.L. (IT) 2008-03-20 WO disclosed