Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.41 |
| ▸ | TLR2 | O60603 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557772 | 0.93 | NPC1 (0.35) | MDM2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8079493 | 0.92 | MEN1 (0.40) | MDM2NPC1RAB9APTPN1MEN1 | |
| SCHEMBL5330706 | 0.87 | NPC1 (0.36) | MDM2NPC1RAB9AMEN1KMT2A | |
| Norleucine SCHEMBL7204454 | 0.82 | SLC1A5 (0.36) | MDM2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2990766 | 0.82 | MEN1 (0.43) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4841403 | 0.82 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL17500350 | 0.81 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7185186 | 0.80 | NPC1 (0.34) | MDM2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL303625 | 0.80 | NPC1 (0.42) | NPC1RAB9APTPN1MEN1KMT2A | |
| SCHEMBL3433024 | 0.79 | HSD17B10 (0.39) | NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053001-B1 | NOVEL MIXED AMYLIN ACTIVITY COMPOUNDS | AMYLIN PHARMACEUTICALS INC (US) | 2010-12-15 | — | — | EP | disclosed |
| EP-1053001-A4 | NOVEL MIXED AMYLIN ACTIVITY COMPOUNDS | AMYLIN PHARMACEUTICALS INC (US) | 2006-01-04 | — | — | EP | disclosed |
| US-6936584-B1 | Mixed amylin activity compounds | AMYLIN PHARMACEUTICALS, INC. (US) | 2005-08-30 | — | — | US | disclosed |
| EP-1053001-A1 | NOVEL MIXED AMYLIN ACTIVITY COMPOUNDS | AMYLIN PHARMACEUTICALS, INC. (US) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999040928-A1 | NOVEL MIXED AMYLIN ACTIVITY COMPOUNDS | AMYLIN PHARMACEUTICALS, INC. (US) | 1999-08-19 | — | — | WO | disclosed |