Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17500350 | 0.94 | NPC1 (0.43) | NPC1RAB9AHSD17B10KMT2AMEN1 | |
| SCHEMBL303625 | 0.90 | NPC1 (0.42) | NPC1RAB9AHSD17B10KMT2AMEN1 | |
| SCHEMBL3433024 | 0.88 | HSD17B10 (0.39) | NPC1RAB9AHSD17B10KMT2AMEN1 | |
| SCHEMBL4784032 | 0.87 | FABP5 (0.41) | RAB9AKMT2AMEN1TSHRFABP5 | |
| SCHEMBL7557772 | 0.86 | NPC1 (0.35) | NPC1RAB9AHSD17B10KMT2AMEN1 | |
| SCHEMBL1526171 | 0.86 | FABP5 (0.40) | RAB9AKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL28069712 | 0.86 | FABP5 (0.45) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2990766 | 0.86 | MEN1 (0.43) | NPC1RAB9AHSD17B10KMT2AMEN1 | |
| SCHEMBL208874 | 0.85 | FABP5 (0.41) | RAB9AKMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL3499128 | 0.85 | HSD17B10 (0.36) | NPC1RAB9AHSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233888-B1 | IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-02-22 | — | — | EP | disclosed |
| US-20210388051-A1 | SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ANCHORED LYSINE | CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S A (GR) | 2021-12-16 | — | — | US | disclosed |
| US-9861680-B2 | Immunomodulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160175386-A1 | Immunomodulators | BRISTOL-MYERS SQUIBB COMPANY | 2016-06-23 | — | — | US | disclosed |
| US-20160031962-A1 | SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ACHORED LYSINE | CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A. (GR) | 2016-02-04 | — | — | US | disclosed |
| EP-2838915-A1 | SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ANCHORED LYSINE | Barlos, Kleomenis K. (GR) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013156977-A1 | SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ANCHORED LYSINE | BARLOS KLEOMENIS K (GR) | 2013-10-24 | — | — | WO | disclosed |
| US-7446120-B2 | Peptidomimetic modulators of cell adhesion | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-11-04 | — | — | US | disclosed |
| US-20080260829-A1 | Bone morphogenic proteins (bmp); cell adhesion modulating agent; peptidomimetics of cyclic peptides comprising classical cadherin cell adhesion recognition (CAR) sequences; modulate cell adhesion and improve drug delivery | NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY (US) | 2008-10-23 | — | — | US | disclosed |
| US-20080081831-A1 | PEPTIDOMIMETIC MODULATORS OF CELL ADHESION | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-04-03 | — | — | US | disclosed |
| US-7268115-B2 | Cyclic peptides; three-dimensional structures; screening; anticancer agents; angiogenesis inhibitors; drug delivery | ADHEREX TECHNOLOGIES, INC. (CA) | 2007-09-11 | — | — | US | disclosed |
| US-20040142854-A1 | Compounds and methods for stimulating beta-catenin mediated gene expression and differentiation | ADHEREX TECHNOLOGIES, INC. (CA) | 2004-07-22 | — | — | US | disclosed |
| US-6706685-B1 | Compounds and methods for stimulating β-catenin mediated gene expression and differentiation | ADHEREX TECHNOLOGIES INC. (CA) | 2004-03-16 | — | — | US | disclosed |
| US-20020168761-A1 | Peptidomimetic modulators of cell adhesion | ADHERFX TECHNOLOGIES, INC. (CA) | 2002-11-14 | — | — | US | disclosed |
| WO-2001053331-A9 | PEPTIDOMIMETIC MODULATORS OF CELL ADHESION | ADHEREX TECHNOLOGIES INC (CA) | 2002-10-31 | — | — | WO | disclosed |
| WO-2001053331-A2 | PEPTIDOMIMETIC MODULATORS OF CELL ADHESION | ADHEREX TECHNOLOGIES, INC. (CA) | 2001-07-26 | — | — | WO | disclosed |
| WO-2000059939-A1 | COMPOUNDS AND METHODS FOR STIMULATING β-CATENIN MEDIATED GENE EXPRESSION AND DIFFERENTIATION | ADHEREX TECHNOLOGIES INC. (CA) | 2000-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160175386-A1 | Immunomodulators | CD274, PDCD1, PDCD1LG2 | NPC1 3367/4885RAB9A 1856/4885HSD17B10 4444/4885 |
| US-20160031962-A1 | SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ACHORED LYSINE | IAPP, INSRR, IGFBP6 | NPC1 2844/4885RAB9A 4440/4885HSD17B10 2490/4885 |
| US-20210388051-A1 | SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ANCHORED LYSINE | IAPP, INSR, INSRR | NPC1 2842/4885RAB9A 4503/4885HSD17B10 3149/4885 |
| US-20080260829-A1 | Bone morphogenic proteins (bmp); cell adhesion modulating agent; peptidomimetics of cyclic peptides comprising classical cadherin cell adhesion recognition (CAR) sequences; modulate cell adhesion and improve drug delivery | BMP1, BMP2, BMP4 | NPC1 2446/4885RAB9A 248/4885HSD17B10 4481/4885 |
| US-20080081831-A1 | PEPTIDOMIMETIC MODULATORS OF CELL ADHESION | CDH1, EPCAM, VCAM1 | NPC1 4627/4885RAB9A 2023/4885HSD17B10 4125/4885 |
| US-20020168761-A1 | Peptidomimetic modulators of cell adhesion | CDH1, EPCAM, VCAM1 | NPC1 4627/4885RAB9A 2023/4885HSD17B10 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.