Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.34 |
| ▸ | TGM2 | P21980 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384949 | 0.94 | BCL2 (0.33) | PRKCIALDH1A1LMNACDK2CDK9 | |
| SCHEMBL3415634 | 0.91 | KDM4E (0.39) | PRKCIALDH1A1LMNACSNK2A2CSNK2B | |
| SCHEMBL3387032 | 0.88 | MAPK1 (0.34) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL3386489 | 0.88 | PRKCI (0.40) | PRKCIALDH1A1LMNACSNK2A2CSNK2B | |
| SCHEMBL3415890 | 0.86 | ESR1 (0.40) | ALDH1A1LMNAESR1SMN1; SMN2 | |
| SCHEMBL2368417 | 0.86 | SMN1; SMN2 (0.37) | PRKCIALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL3384941 | 0.80 | ALDH1A1 (0.38) | PRKCIALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL2369294 | 0.80 | TGM2 (0.36) | ALDH1A1LMNATGM2ESR1KDM4E | |
| SCHEMBL3387551 | 0.80 | DYRK1A (0.40) | ALDH1A1LMNAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL2368869 | 0.79 | PRKCI (0.43) | PRKCIALDH1A1LMNACSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |