Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386501 | 0.94 | PRKCI (0.36) | ALDH1A1KDM4ESMN1; SMN2HPGDPRKCI | |
| SCHEMBL2368417 | 0.90 | SMN1; SMN2 (0.37) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL3384941 | 0.88 | ALDH1A1 (0.38) | ALDH1A1KDM4ESMN1; SMN2NPSR1MEN1 | |
| SCHEMBL3387032 | 0.87 | MAPK1 (0.34) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL2369294 | 0.87 | TGM2 (0.36) | ALDH1A1KDM4ESMN1; SMN2KMT2AHPGD | |
| SCHEMBL3415634 | 0.85 | KDM4E (0.39) | ALDH1A1KDM4ESMN1; SMN2NPSR1MEN1 | |
| SCHEMBL3386489 | 0.82 | PRKCI (0.40) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL3415890 | 0.80 | ESR1 (0.40) | MCL1ALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL2369569 | 0.80 | PRKCI (0.37) | ALDH1A1KDM4ENPSR1MEN1KMT2A | |
| Butane SCHEMBL6359344 | 0.79 | SMN1; SMN2 (0.41) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |