Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824798 | 0.80 | LMNA (0.40) | NPC1POLBRAB9AKDM4EHTT | |
| SCHEMBL20272946 | 0.77 | ALDH1A1 (0.44) | ALDH1A1NPC1POLBRAB9AKDM4E | |
| SCHEMBL997757 | 0.75 | ALDH1A1 (0.54) | ALDH1A1NPC1POLBRAB9AKDM4E | |
| SCHEMBL13156531 | 0.73 | ALDH1A1 (0.46) | ALDH1A1NPC1POLBRAB9AKDM4E | |
| SCHEMBL1867993 | 0.72 | — | — | |
| SCHEMBL8170243 | 0.72 | ALDH1A1 (0.54) | ALDH1A1NPC1POLBRAB9AKDM4E | |
| SCHEMBL3417508 | 0.71 | ALDH1A1 (0.36) | ALDH1A1NPC1POLBRAB9AKDM4E | |
| SCHEMBL29384237 | 0.71 | ALDH1A1 (0.48) | ALDH1A1NPC1POLBRAB9AKDM4E | |
| SCHEMBL832575 | 0.71 | ALDH1A1 (0.48) | ALDH1A1NPC1POLBRAB9AKDM4E | |
| SCHEMBL28910441 | 0.71 | ALDH1A1 (0.48) | ALDH1A1NPC1POLBRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848723-B1 | NEW ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS INC (US) | 2010-12-15 | — | — | EP | disclosed |
| EP-0514268-A1 | Substituted amino acid azetidinyl pyridone derivatives, their preparation and use as medicines | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-11-19 | — | — | EP | disclosed |
| US-5087621-A | Microbiocides | LABORATORIOS DEL DR. ESTEVE (ES) | 1992-02-11 | — | — | US | disclosed |
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| EP-0394120-A1 | Substituted azetidinyl isothiazolo-pyrydone derivatives, their preparation and their use as medicines | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1990-10-24 | — | — | EP | disclosed |
| US-4880814-A | 7-cycloalkyl naphthyridines | ABBOTT LABORATORIES (US) | 1989-11-14 | — | — | US | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |
| EP-0227088-A1 | Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives | ABBOTT LABORATORIES (US) | 1987-07-01 | — | — | EP | disclosed |