Hydrochloric Acid

Hydrochloric Acid

SCHEMBL338847

CC1=Cc2c(ccc3ccccc23)C1[Zr+2](C1C(C)=Cc2c1ccc1ccccc21)=[Si](C)C.[Cl-].[Cl-]

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 1/20 0.30
SLC6A3 known ✓ Q01959 1/20 0.30
KDM4E B2RXH2 3/20 0.37
ALDH1A1 P00352 5/20 0.34
CYP2A6 P11509 4/20 0.34
TSHR P16473 3/20 0.33
CYP1A2 P05177 2/20 0.33
HSD17B10 Q99714 4/20 0.32
HPGD P15428 3/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32
KDM1A O60341 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
SLC6A4 P31645 2/20 0.31
CYP3A4 P08684 2/20 0.30
MAPK1 P28482 1/20 0.30
CASP1 P29466 1/20 0.30
RAB9A P51151 1/20 0.30
CASP7 P55210 1/20 0.30
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7936177 0.86 KDM4E (0.34) KDM4EALDH1A1CYP2A6
Hydrochloric Acid SCHEMBL1009752 0.86 KDM4E (0.32) KDM4EALDH1A1CYP2A6HPGDMAPT
Hydrochloric Acid SCHEMBL3735435 0.85 KDM4E (0.33) KDM4EALDH1A1CYP2A6TSHRCYP1A2
Hydrochloric Acid SCHEMBL6908205 0.84 MEN1 (0.32)
Fluoride Ion SCHEMBL31126405 0.83 KDM4E (0.32) KDM4EALDH1A1CYP2A6HPGDMAPT
Hydrochloric Acid SCHEMBL8571945 0.83 KDM4E (0.30) KDM4EKDM1A
Hydrochloric Acid SCHEMBL6466483 0.82 ALDH1A1 (0.36) KDM4EALDH1A1CYP2A6TSHRCYP1A2
Hydrochloric Acid SCHEMBL7926973 0.82 KDM4E (0.35) KDM4E
Hydrochloric Acid SCHEMBL3814873 0.80 ALDH1A1 (0.34) ALDH1A1TSHRCYP1A2HSD17B10HPGD
Hydrochloric Acid SCHEMBL3807132 0.80 CES1 (0.33) ALDH1A1CYP1A2HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9718898-B1 Homogeneous polymerization catalyst for alpha olefins LION COPOLYMER GEISMAR, LLC (US) 2017-08-01 US claimed
US-9718897-B1 Process for the polymerization or copolymerization of an alpha olefin LION COPOLYMER GEISMAR, LLC (US) 2017-08-01 US claimed
US-8975202-B2 Polymerization catalysts and method for preservation of same IDEMITSU KOSAN CO., LTD. (JP) 2015-03-10 US claimed
US-20120129683-A1 POLYMERIZATION CATALYSTS AND METHOD FOR PRESERVATION OF SAME IDEMITSU KOSAN CO., LTD. (JP) 2012-05-24 US claimed
EP-1004603-B1 POLYDISPERSE PROPYLENE POLYMER AND PROCESS FOR PRODUCING THE SAME CHISSO CORP (JP) 2003-01-15 EP claimed
US-6441111-B1 MULTISTAGE POLYMERIZATION WHERE CONDITIONS ARE STEPWISE CHANGED IN THE PRESENCE OF A SUPPORTED METALLOCENE CATALYST OF GIVEN TRANSITION METAL COMPOUND AND AN ALUMOXANE ON A FINELY PARTICULATE SUPPORT, AND AN ORGANOALUMINUM COMPOUND CHISSO CORPORATION (JP) 2002-08-27 US claimed
EP-1004603-A1 POLYDISPERSE PROPYLENE POLYMER AND PROCESS FOR PRODUCING THE SAME CHISSO CORPORATION (JP) 2000-05-31 EP claimed
US-10246531-B2 Production method for olefin-based polymer, olefin polymerization catalyst, and olefin-based polymer IDEMITSU KOSAN CO., LTD. (JP) 2019-04-02 US disclosed
US-10150825-B2 Production method for olefin-based polymer, and olefin polymerization catalyst IDEMITSU KOSAN CO., LTD. (JP) 2018-12-11 US disclosed
US-9919300-B2 1-hexene production process SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-03-20 US disclosed
EP-2484685-B1 TRANSITION METAL COMPLEX, PREPARATION METHOD FOR SAID TRANSITION METAL COMPLEX, TRIMERIZATION CATALYST, PREPARATION METHOD FOR 1-HEXENE, PREPARATION METHOD FOR ETHYLENE POLYMER, SUBSTITUTED CYCLOPENTADIENE COMPOUND, AND PREPARATION METHOD FOR SAID SUBSTITUTED CYCLOPENTADIENE COMPOUND SUMITOMO CHEMICAL CO (JP) 2017-11-01 EP disclosed
US-9718898-B1 Homogeneous polymerization catalyst for alpha olefins LION COPOLYMER GEISMAR, LLC (US) 2017-08-01 US disclosed
US-9718897-B1 Process for the polymerization or copolymerization of an alpha olefin LION COPOLYMER GEISMAR, LLC (US) 2017-08-01 US disclosed
EP-0870804-A1 Olefin (co)polymer composition CHISSO CORPORATION (JP) 1998-10-14 EP disclosed
EP-0834514-A2 Process for synthesizing metallocene compounds KANTO KAGAKU KABUSHIKI KAISHA (JP) 1998-04-08 EP disclosed
EP-0692505-B1 Process for procucing propylene block copolymers MITSUBISHI CHEM CORP (JP) 1998-01-28 EP disclosed
EP-0783022-A1 ETHYLENIC POLYMER COMPOSITION MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1997-07-09 EP disclosed
US-5623022-A VAPOR PHASE; USING COORDINATION CATALYST MITSUBISHI CHEMICAL CORPORATION (JP) 1997-04-22 US disclosed
EP-0728773-A1 Catalysts for olefin polymerization and a process for preparing olefin polymers therewith MITSUBISHI CHEMICAL CORPORATION (JP) 1996-08-28 EP disclosed
EP-0692505-A2 Process for procucing propylene block copolymers MITSUBISHI CHEMICAL CORPORATION (JP) 1996-01-17 EP disclosed