Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6463184 | 0.85 | DHFR (0.35) | ALDH1A1CYP2A6KDM4EHPGDMAPT | |
| Hydrochloric Acid SCHEMBL6463028 | 0.82 | KDM4E (0.34) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL19520611 | 0.82 | KDM4E (0.34) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL338847 | 0.82 | KDM4E (0.37) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7217830 | 0.82 | KDM4E (0.34) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7725653 | 0.82 | KDM4E (0.34) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL247996 | 0.82 | KDM4E (0.34) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 | |
| Ethane SCHEMBL8633166 | 0.81 | ALDH1A1 (0.34) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL5702868 | 0.79 | KDM4E (0.38) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7938953 | 0.79 | KDM4E (0.33) | ALDH1A1CYP2A6KDM4ETSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900343-B1 | Method for the purification of metallocenes | BASELL POLYOLEFINE GMBH (DE) | 2005-05-31 | — | — | US | disclosed |
| EP-1153938-A1 | CATALYST FOR STEREOREGULAR POLYMERIZATION OF ALPHA-OLEFIN AND PROCESS FOR PRODUCING STEREOREGULAR ALPHA-OLEFIN POLYMER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-11-14 | — | — | EP | disclosed |