Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 7/20 | 0.68 |
| ▸ | HTR3B | O95264 | 7/20 | 0.68 |
| ▸ | HTR3A | P46098 | 7/20 | 0.68 |
| ▸ | HTR3D | Q70Z44 | 7/20 | 0.68 |
| ▸ | HTR3C | Q8WXA8 | 7/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29278836 | 0.94 | HTR3E (0.62) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL16798958 | 0.80 | HTR3E (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL27950444 | 0.80 | HTR3E (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2812938 | 0.80 | ALDH1A1 (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6892243 | 0.78 | HTR3E (0.60) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL15229159 | 0.76 | PARP1 (0.42) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29278835 | 0.76 | ALDH1A1 (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL3392869 | 0.76 | C1S (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL5557095 | 0.76 | SIGMAR1 (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Guanidine SCHEMBL28302967 | 0.75 | HTR3E (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048164-A2 | N,N'-DI-P-BROMOPHENYL GUANIDINE TREATMENT FOR STROKE AT DELAYED TIMEPOINTS | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-04-29 | — | — | WO | claimed |