Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.35 |
| ▸ | PSMD11 | O00231 | 2/20 | 0.35 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.35 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.35 |
| ▸ | PSMD3 | O43242 | 2/20 | 0.35 |
| ▸ | PSMC3 | P17980 | 2/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.35 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.35 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.35 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.35 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.35 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.35 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.35 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
| ▸ | PSMC2 | P35998 | 2/20 | 0.35 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1051333 | 1.00 | PSMB11 (0.35) | PSMB11PSMD11PSMD12PSMD14PSMA7 | |
| SCHEMBL3389166 | 1.00 | PSMB11 (0.35) | PSMB11PSMD11PSMD12PSMD14PSMA7 | |
| SCHEMBL1047524 | 0.89 | KLK7 (0.40) | HTR2CKLK7KLK5 | |
| SCHEMBL3390160 | 0.89 | KLK7 (0.40) | HTR2CKLK7KLK5 | |
| SCHEMBL3390164 | 0.89 | KLK7 (0.40) | HTR2CKLK7KLK5 | |
| SCHEMBL27847181 | 0.77 | EPHX2 (0.42) | PSMB11PSMD11PSMD12PSMD14PSMA7 | |
| SCHEMBL3465573 | 0.77 | — | — | |
| SCHEMBL3465570 | 0.77 | — | — | |
| SCHEMBL3387963 | 0.76 | — | — | |
| SCHEMBL3387960 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756037-B1 | AMINO ALCOHOL DERIVATIVES AND THEIR ACTIVITY AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| US-7786307-B2 | suchas N-(4(S)-amino-5(S)-hydroxy-2(S)-isopropyl-6-piperidin-1-ylhexyl)-2-(3-methoxypropoxy)benzamide dihydrochloride, used for the treatment of hypertension, cardiovasculr disorders, complications owing to diabetes, vision deffects, hyperaldosteronism, states of anxiety and cognitive disorders | NOVARTIS AG (CH) | 2010-08-31 | — | — | US | disclosed |
| US-20070155743-A1 | Amino alcohol derivatives and their activity as renin inhibitors | NOVARTIS PHARMA AG (CH) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155743-A1 | Amino alcohol derivatives and their activity as renin inhibitors | REN, AGTR1, AGTR2 | PSMB11 1066/4885PSMD11 1959/4885PSMD12 2786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.