Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | DAO | P14920 | 1/20 | 0.66 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.66 |
| ▸ | RHEB | Q15382 | 1/20 | 0.56 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30071340 | 0.88 | SMAD3 (0.60) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL20494223 | 0.88 | SMAD3 (0.60) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL3643396 | 0.87 | SMAD3 (0.55) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL30071319 | 0.87 | F7 (0.61) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL3500068 | 0.87 | F7 (0.61) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL7493915 | 0.87 | KDM4E (0.61) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL7222628 | 0.87 | PIN1 (0.61) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL30071390 | 0.87 | KDM4E (0.61) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL22777743 | 0.86 | KDM4E (0.66) | HSD17B10KDM4EHPGDMAPTDAO | |
| SCHEMBL3700465 | 0.86 | KDM4E (0.66) | HSD17B10KDM4EHPGDMAPTDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239771-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. | 2024-07-18 | — | — | US | disclosed |
| US-20240239771-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. | 2024-07-18 | — | — | US | disclosed |
| WO-2021243273-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |
| WO-2021243273-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
| WO-2010003963-A1 | USE OF OPIOID ANTAGONISTS FOR TREATING URINARY RETENTION | EURO-CELTIQUE S.A. (LU) | 2010-01-14 | — | — | WO | disclosed |
| WO-2009158375-A1 | AZA-CYLIC INDOLE- 2 -CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-12-30 | — | — | WO | disclosed |
| US-6759428-B2 | SUCH AS N-((1,2)-2-(((CYANO(CYCLOPROPYL)METHYL)AMINO)CARBONYL) CYCLOHEXYL)-1H-INDOLE-2-CARBOXAMIDE; CATHEPSIN K INHIBITORS | ROCHE PALO ALTO LLC | 2004-07-06 | — | — | US | disclosed |
| US-20040077646-A1 | Indole nitriles | ROCHE PALO ALTO LLC | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | HSD17B10 2072/4885KDM4E 963/4885HPGD 638/4885 |
| US-20040077646-A1 | Indole nitriles | TPH1, IDO1, NAT1 | HSD17B10 2073/4885KDM4E 3071/4885HPGD 1353/4885 |
| US-20240239771-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, SLC47A1 | HSD17B10 489/4885KDM4E 4432/4885HPGD 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.