Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30100746 | 1.00 | POLB (0.51) | POLBCYP2A6SRD5A1OPRM1OPRK1 | |
| SCHEMBL8164410 | 0.88 | MEN1 (0.50) | POLBCYP2A6MEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1977939 | 0.86 | MEN1 (0.49) | POLBCYP2A6MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11677341 | 0.84 | HTR2A (0.50) | POLBSRD5A1OPRM1OPRK1HTR2A | |
| Hydrochloric Acid SCHEMBL11818641 | 0.82 | HTR2A (0.48) | POLBSRD5A1OPRM1OPRK1HTR2A | |
| SCHEMBL1462133 | 0.81 | HPGD (0.55) | CYP2A6OPRM1OPRK1OPRL1MEN1 | |
| SCHEMBL30642087 | 0.81 | HPGD (0.55) | CYP2A6OPRM1OPRK1OPRL1MEN1 | |
| Hydrochloric Acid SCHEMBL27671303 | 0.79 | HPGD (0.53) | CYP2A6OPRM1OPRK1OPRL1MEN1 | |
| SCHEMBL26077071 | 0.79 | HRH1 (0.51) | POLBCYP2A6SRD5A1MEN1KMT2A | |
| SCHEMBL761220 | 0.75 | SRD5A1 (0.54) | POLBCYP2A6SRD5A1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2952503-A1 | HIV REPLICATION INHIBITOR | Shionogi & Co., Ltd. (JP) | 2015-12-09 | — | — | EP | disclosed |
| WO-2015156421-A1 | DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2015-10-15 | — | — | WO | disclosed |
| US-9115151-B2 | Substituted 2,10-dihydro-9-oxa-1,2,4A-triazaphenanthren-3-ones and uses thereof | ABBVIE INC. (US) | 2015-08-25 | — | — | US | disclosed |
| CN-104364253-A | Tricyclic compounds as kat ii inhibitors | PFIZER | 2015-02-18 | — | — | CN | disclosed |
| EP-2772480-A1 | HIV REPLICATION INHIBITOR | Shionogi & Co., Ltd. (JP) | 2014-09-03 | — | — | EP | disclosed |
| US-20140206663-A1 | TRIAZINONE COMPOUNDS | WUXI APPTECH (SHANGHAI) CO., LTD. (CN) | 2014-07-24 | — | — | US | disclosed |
| WO-2014089904-A1 | TRIAZINONE COMPOUNDS | ABBVIE INC. (US) | 2014-06-19 | — | — | WO | disclosed |
| EP-1560827-B1 | ANTI-INFECTIVE AGENTS | ABBOTT LAB (US) | 2010-12-29 | — | — | EP | disclosed |
| US-7605265-B2 | Heterodimers and methods of using them | Biotechnology Research Corporation Ltd. (CN) | 2009-10-20 | — | — | US | disclosed |
| US-20080176308-A1 | Heterodimers and Methods of Using Them | BIOTECHNOLOGY RESEARCH CORPORATION LIMITED (CN) | 2008-07-24 | — | — | US | disclosed |
| WO-2007022280-A1 | PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |
| US-20060160814-A1 | Phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2006-07-20 | — | — | US | disclosed |
| WO-2006028957-A1 | 4-SUBSTITUTED 4, 6-DIALKOXY-CINNOLINE DERIVATIVES AS PHOSPODIESTERASE 10 INHIBITORS FOR THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL SYNDROMS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2005123685-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |
| US-5594006-A | SUCH AS COLLEGENASE, STROMELYSIN; ANTICANCER AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| WO-1996036596-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |
| EP-0641323-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |
| WO-1994021612-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-29 | — | — | WO | disclosed |
| CN-1063686-A | With the synthetic vesnarinone of active ester method | MEDICINE INST HUAXI MEDICAL UN (CN) | 1992-08-19 | — | — | CN | disclosed |
| CN-1063686-A | With the synthetic vesnarinone of active ester method | MEDICINE INST HUAXI MEDICAL UN (CN) | 1992-08-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206663-A1 | TRIAZINONE COMPOUNDS | THPO, IL5, CYP11B2 | POLB 2191/4885CYP2A6 60/4885SRD5A1 191/4885 |
| US-20060160814-A1 | Phosphodiesterase 10 inhibitors | PDE5A, PDE3A, PDE2A | POLB 943/4885CYP2A6 2262/4885SRD5A1 584/4885 |
| US-20080176308-A1 | Heterodimers and Methods of Using Them | GRIN2A, GRIN3A, GRIN1 | POLB 1652/4885CYP2A6 4610/4885SRD5A1 2071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.