Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL339672 | 0.96 | KMT2A (0.53) | BRD4ALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL338498 | 0.96 | MEN1 (0.50) | BRD4ALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL339133 | 0.95 | SGMS2 (0.54) | BRD4ALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL337855 | 0.85 | IDH1 (0.49) | BRD4ALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL13395924 | 0.82 | BRD4 (0.50) | BRD4ALDH1A1MAOBIDH1MMP3 | |
| SCHEMBL338697 | 0.82 | IDH1 (0.50) | ALDH1A1MEN1KMT2AMAOBIDH1 | |
| SCHEMBL338935 | 0.80 | IDH1 (0.48) | ALDH1A1MEN1KMT2AIDH1MMP3 | |
| SCHEMBL2984201 | 0.78 | MMP3 (0.72) | ALDH1A1MEN1KMT2AMMP3MMP12 | |
| SCHEMBL13208646 | 0.78 | MMP3 (0.59) | MEN1KMT2AMAOBSGMS2IDH1 | |
| SCHEMBL14260034 | 0.78 | MMP3 (0.59) | ALDH1A1SGMS2MMP3MMP12MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687298-B1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC (CA) | 2012-12-26 | — | — | EP | disclosed |
| US-8097624-B2 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | APOTEX INC. (CA) | 2012-01-17 | — | — | US | disclosed |
| US-20090170850-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | APOTEX INC. | 2009-07-02 | — | — | US | disclosed |
| CN-100448873-C | Cycloalkyl derivatives of 3-hydroxy-4-pyridones | APOTEX INC (CA) | 2009-01-07 | — | — | CN | disclosed |
| US-7410985-B2 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | APOTEX INC. (CA) | 2008-08-12 | — | — | US | disclosed |
| EP-1687298-A4 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC (CA) | 2007-10-17 | — | — | EP | disclosed |
| US-20070082904-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones field of the invention | APOTEX INC. (CA) | 2007-04-12 | — | — | US | disclosed |
| CN-1926135-A | Cycloalkyl derivatives of 3-hydroxy-4-pyridones | APOTEX INC (CA) | 2007-03-07 | — | — | CN | disclosed |
| EP-1687298-A1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | Apotex Inc. (CA) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049609-A1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC. (CA) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170850-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | HAMP, C1S, C1R | BRD4 2077/4885ALDH1A1 1709/4885MEN1 883/4885 |
| US-20070082904-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones field of the invention | HAMP, C1S, SLC40A1 | BRD4 1995/4885ALDH1A1 3337/4885MEN1 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.