Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 14/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390173 | 0.89 | AVPR1A (0.54) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL3100321 | 0.81 | PLD2 (0.66) | HSD11B1CHRM1 | |
| SCHEMBL3100311 | 0.78 | HSD11B1 (0.63) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL1833332 | 0.77 | HSD11B1 (0.68) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL5774178 | 0.76 | HSD11B1 (0.67) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL1760919 | 0.76 | HSD11B1 (0.67) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL3106327 | 0.76 | HSD11B1 (0.67) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL29872667 | 0.76 | HSD11B1 (0.67) | HSD11B1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL3392349 | 0.76 | L3MBTL1 (0.59) | CHRM4 | |
| SCHEMBL4669587 | 0.76 | CHRM1 (0.91) | HSD11B1CHRM1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |