Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | USP2 | O75604 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751254 | 0.76 | ALDH1A1 (0.70) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3390119 | 0.76 | HSD11B1 (0.60) | CHRM4 | |
| SCHEMBL3393806 | 0.72 | UBE2M (0.62) | MEN1KMT2AALDH1A1MAPTHSD17B10 | |
| SCHEMBL27575531 | 0.72 | HPGD (0.49) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3100293 | 0.71 | FPR2 (0.63) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4405502 | 0.71 | ALDH1A1 (0.62) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL5633033 | 0.70 | USP2 (0.58) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4777481 | 0.69 | L3MBTL1 (0.61) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| Lithium Ion SCHEMBL5633232 | 0.69 | USP2 (0.57) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL825280 | 0.68 | AVPR1A (0.67) | L3MBTL1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |