Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394251 | 0.96 | PTK2B (0.39) | LMNAPTK2BMAPTMAPK1ALDH1A1 | |
| SCHEMBL3392512 | 0.94 | PTK2B (0.36) | PTK2BTNFRAB9ANOD1MAPT | |
| SCHEMBL3389398 | 0.93 | PTK2B (0.36) | LMNAPTK2BTNFRAB9ANOD1 | |
| SCHEMBL3393200 | 0.93 | PTK2B (0.37) | LMNAPTK2BRAB9AMAPTMAPK1 | |
| SCHEMBL3393248 | 0.93 | MAPT (0.43) | LMNAPTK2BMAPTMAPK1ALDH1A1 | |
| SCHEMBL3392832 | 0.91 | BRAF (0.35) | LMNAPTK2BTP53BRAFMAPK14 | |
| SCHEMBL3390664 | 0.91 | BRAF (0.35) | LMNAPTK2BMAPTMAPK1ALDH1A1 | |
| SCHEMBL3394297 | 0.90 | PTK2B (0.40) | LMNAPTK2BALDH1A1KDM4EKMT2A | |
| SCHEMBL3174404 | 0.90 | MAPK14 (0.38) | LMNAPTK2BMAPTALDH1A1HTT | |
| SCHEMBL3391076 | 0.89 | PHGDH (0.40) | PTK2BALDH1A1KDM4EMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |