Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL872577 | 0.97 | MEN1 (0.57) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27920550 | 0.97 | MEN1 (0.57) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL2351951 | 0.92 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL339062 | 0.92 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3790706 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872580 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL15527809 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3790708 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3791421 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872578 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 373 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260015560-A1 | COMPOSITIONS FOR POST-CMP CLEANING OF MICROELECTRONIC DEVICES | ENTEGRIS INC (US) | 2026-01-15 | — | — | US | claimed |
| WO-2025129288-A1 | COMPOSITIONS AND METHODS FOR TREATING KERATIN FIBERS | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025132928-A1 | PROCESS FOR LIGHTENING KERATIN FIBERS USING A PEROXYGENATED SALT, AN OSMOLYTE AND A HYDROXYLATED POLYCARBOXYLIC ACID | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129296-A1 | METHODS FOR TREATING KERATIN FIBERS WITH OSMOLYTES, CARBOXYLIC ACID AND AMINO ACIDS | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129294-A1 | METHODS FOR TREATING KERATIN FIBERS WITH OSMOLYTES, CARBOXYLIC ACID AND AMINO ACIDS | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129295-A1 | COMPOSITIONS AND METHODS FOR TREATING HAIR | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129293-A1 | METHODS FOR TREATING KERATIN FIBERS WITH OSMOLYTES, CARBOXYLIC ACID AND AMINO ACIDS | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129292-A1 | METHODS FOR TREATING KERATIN FIBERS WITH OSMOLYTES, CARBOXYLIC ACID AND AMINO ACIDS | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129302-A1 | COMPOSITION FOR TREATING KERATIN FIBERS AND METHOD FOR TREATING KERATIN FIBERS | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025129285-A1 | COMPOSITIONS AND METHODS FOR IMPROVING PENETRATION OF ACTIVE AGENTS FOR KERATIN FIBERS | L'OREAL (FR) | 2025-06-26 | — | — | WO | claimed |
| WO-2006032958-A2 | COMPOSITION IN MICRO-PELLETS WITH CONTROLLED RELEASE PHYSIOLOGICALLY ACTIVE SUBSTANCE, PROCEDURE FOR THEIR PREPARATION AND USE IN THE ZOOTECHENICAL SECTOR | ASCOR CHIMICI S.R.L. (IT) | 2006-03-30 | — | — | WO | claimed |
| US-20060067984-A1 | Composition in micro-pellets with controlled release of physiologically active substances, procedure for their preparation and use in the zootechnical sector | BALCHEM ITALIA S.R.L. (IT) | 2006-03-30 | — | — | US | claimed |
| EP-0730018-B1 | Improved water-based drilling fluids for reduction of water adsorption and hydration of argillaceous rocks | MI LLC (US) | 2003-05-14 | — | — | EP | claimed |
| US-5972862-A | COMPRISING A FLUORINE-CONTAINING COMPOUND, A WATER-SOLUBLE OR WATER-MISCIBLE ORGANIC SOLVENT, AN ORGANIC ACID, AND A QUATERNARY AMMONIUM SALT | MITSUBISHI GAS CHEMICAL (JP) | 1999-10-26 | — | — | US | claimed |
| US-5807594-A | PROTECTIVE COATING INCREASES STABILITY | DUCOA, L.P. (US) | 1998-09-15 | — | — | US | claimed |
| WO-1998037774-A1 | FEEDSTUFF ADDITIVE AND METHOD FOR ENHANCING FEED EFFICIENCY IN RUMINANTS | DUCOA L.P. (US) | 1998-09-03 | — | — | WO | claimed |
| US-5635458-A | CONTAINING LOW MOLECULAR WEIGHT GLYCOL, CHOLINE SALT, FILTRATION CONTROL AGENT AND VISCOSIFIER | M-I DRILLING FLUIDS, L.L.C. (US) | 1997-06-03 | — | — | US | claimed |
| EP-0730018-A1 | Improved water-based drilling fluids for reduction of water adsorption and hydration of argillaceous rocks | M-I Drilling Fluids L.L.C. (US) | 1996-09-04 | — | — | EP | claimed |
| CN-1081569-A | agricultural composition for promoting plant photosynthesis | SWALLOW ENTERPRISES CO (HK) | 1994-02-09 | — | — | CN | claimed |
| US-5209858-A | By adding an unsubstituted hydroxylamine salt to its solution | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-05-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260015560-A1 | COMPOSITIONS FOR POST-CMP CLEANING OF MICROELECTRONIC DEVICES | TET2, ASIC1, PIEZO1 | MEN1 2976/4885KMT2A 778/4885LMNA 2078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.