Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL97820 | 0.79 | RAB9A (0.49) | ALDH1A1DYRK1ADYRK2DYRK1BNPC1 | |
| SCHEMBL11770226 | 0.79 | TRIM24 (0.71) | TRIM24TRIM33CA12CA1CA2 | |
| SCHEMBL346974 | 0.79 | TRIM24 (0.64) | TRIM24TRIM33CA12CA1CA2 | |
| SCHEMBL3388618 | 0.77 | TGFBR1 (0.48) | TGFBR1NPC1RAB9A | |
| SCHEMBL27621710 | 0.77 | TRIM24 (0.68) | TRIM24TRIM33CA12CA1CA2 | |
| SCHEMBL8337311 | 0.77 | NPC1 (0.52) | TGFBR1DYRK1ANPC1POLBRAB9A | |
| SCHEMBL29700451 | 0.75 | TRIM24 (0.67) | TRIM24TRIM33CA12CA1CA2 | |
| SCHEMBL5916092 | 0.75 | TRIM24 (0.67) | TRIM24TRIM33CA12CA1CA2 | |
| SCHEMBL27906803 | 0.75 | TGFBR1 (0.53) | TGFBR1ALDH1A1CDK5CDK5R1NPC1 | |
| SCHEMBL31313039 | 0.75 | TRIM24 (0.60) | TRIM24TRIM33CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |