Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421956 | 0.86 | PTGDR2 (0.43) | HTR2AHTR2CKCNH2HTR6ALDH1A1 | |
| SCHEMBL1993674 | 0.84 | HTR2A (0.50) | HTR2AHTR2CKCNH2HTR6ALDH1A1 | |
| SCHEMBL2348067 | 0.81 | MEN1 (0.50) | HTR2AHTR2CKCNH2HTR6POLB | |
| SCHEMBL13210565 | 0.77 | HTR2A (0.55) | HTR2AHTR2CKCNH2HTR6 | |
| SCHEMBL1989784 | 0.76 | PTGDR2 (0.58) | HTR2AHTR2CKCNH2ALDH1A1FEN1 | |
| SCHEMBL2908737 | 0.74 | FEN1 (0.43) | HTR2AHTR2CKCNH2HTR6ALDH1A1 | |
| SCHEMBL4126597 | 0.74 | PTGS2 (0.46) | HTR2AHTR2CKCNH2HTR6MAPT | |
| SCHEMBL586329 | 0.73 | HTR6 (0.58) | HTR2AHTR2CKCNH2HTR6ALDH1A1 | |
| SCHEMBL778229 | 0.73 | HTR6 (0.70) | HTR2AHTR2CKCNH2HTR6ALDH1A1 | |
| SCHEMBL7937274 | 0.73 | HTR6 (0.70) | HTR2AHTR2CKCNH2HTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937633-B8 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2010-12-22 | — | — | EP | claimed |
| EP-1937633-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039741-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |