Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602880 | 0.86 | MAPK14 (0.43) | MAPK14CDK8MAPK13CA12CA1 | |
| SCHEMBL3391073 | 0.83 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL3390651 | 0.82 | SMO (0.37) | MAPK14CDK8MAPK13MAPK12MAPK11 | |
| SCHEMBL3390273 | 0.82 | MAPK14 (0.34) | MAPK14CDK8MAPK13MAPK12MAPK11 | |
| SCHEMBL3392905 | 0.81 | SMO (0.39) | MAPK14CDK8MAPK13MAPK12MAPK11 | |
| SCHEMBL3390581 | 0.81 | P2RY12 (0.37) | MAPK14CNR2P2RY12PTK2 | |
| SCHEMBL3392475 | 0.81 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL3180430 | 0.79 | CDK8 (0.35) | MAPK14CDK8MAPK13MAPK12MAPK11 | |
| SCHEMBL4602779 | 0.79 | MAPK13 (0.45) | MAPK14CDK8MAPK13CA12CA1 | |
| SCHEMBL3389956 | 0.79 | RAB9A (0.36) | MAPK14CDK8MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |