Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.54 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.41 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433790 | 0.79 | HPGD (0.61) | HPGDSLC6A7MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3429690 | 0.79 | HPGD (0.61) | HPGDPDE4BPDE4DECE2 | |
| SCHEMBL3435828 | 0.78 | HPGD (0.70) | HPGDSLC6A7MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3435145 | 0.76 | HPGD (0.56) | HPGDMEN1KMT2ASMN1; SMN2PDE4B | |
| SCHEMBL3433125 | 0.75 | HPGD (0.55) | HPGDPDE4BPDE4DECE2 | |
| SCHEMBL4527873 | 0.73 | HPGD (0.97) | HPGDECE2POLB | |
| SCHEMBL2388894 | 0.72 | NAMPT (0.55) | HPGDSLC6A7MAPK7ABL1 | |
| SCHEMBL4525058 | 0.71 | HPGD (1.00) | HPGDSMN1; SMN2ECE2 | |
| SCHEMBL4532102 | 0.71 | HPGD (1.00) | HPGDSMN1; SMN2ECE2 | |
| Cx516 SCHEMBL194605 | 0.71 | HPGD (1.00) | HPGDSMN1; SMN2ECE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |