Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433790 | 0.81 | HPGD (0.61) | HPGDL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL3429690 | 0.81 | HPGD (0.61) | HPGDPDE4BPDE4DECE2KDM4E | |
| SCHEMBL3435828 | 0.79 | HPGD (0.70) | HPGDPOLBMEN1KMT2APDE4B | |
| SCHEMBL13539432 | 0.77 | L3MBTL1 (0.73) | HPGDRXFP1L3MBTL1POLBMEN1 | |
| SCHEMBL3433125 | 0.76 | HPGD (0.55) | HPGDPDE4BPDE4DECE2 | |
| SCHEMBL27182236 | 0.76 | L3MBTL1 (0.71) | HPGDRXFP1L3MBTL1POLBMEN1 | |
| SCHEMBL3391582 | 0.76 | HPGD (0.54) | HPGDPOLBMEN1KMT2APDE4B | |
| SCHEMBL4527873 | 0.74 | HPGD (0.97) | HPGDPOLBECE2ALDH1A1 | |
| Cx516 SCHEMBL194605 | 0.73 | HPGD (1.00) | HPGDECE2ALDH1A1SMN1; SMN2 | |
| Cx516 SCHEMBL31660971 | 0.73 | HPGD (1.00) | HPGDECE2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |