Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PAM | P19021 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391942 | 1.00 | MAOA (0.46) | MAOAMAOBIDO1HCAR2RELA | |
| SCHEMBL5888967 | 0.78 | MAPT (0.37) | HSD17B10 | |
| SCHEMBL9434207 | 0.74 | IDO1 (0.50) | MAOAMAOBIDO1HCAR2RELA | |
| SCHEMBL9434199 | 0.74 | IDO1 (0.50) | MAOAMAOBIDO1HCAR2RELA | |
| SCHEMBL2253339 | 0.73 | LTA4H (0.39) | RELANPC1RAB9APDGFRBPDGFRA | |
| SCHEMBL1158153 | 0.73 | IDO1 (0.61) | MAOAMAOBIDO1RELAPPARA | |
| SCHEMBL11426742 | 0.73 | IDO1 (0.61) | MAOAMAOBIDO1RELAPPARA | |
| SCHEMBL1158152 | 0.73 | IDO1 (0.61) | MAOAMAOBIDO1RELAPPARA | |
| SCHEMBL406684 | 0.72 | ALOX5 (0.53) | MAOAMAOBRAB9AALOX5 | |
| SCHEMBL13610581 | 0.72 | MAOA (0.63) | MAOAMAOBIDO1RELAPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | disclosed |