Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL339357 | 0.88 | CRHR1 (0.39) | CYP1A2CYP3A4CYP2D6NPSR1ALDH1A1 | |
| SCHEMBL338930 | 0.87 | CRHR1 (0.41) | CYP1A2CYP3A4CYP2D6NPSR1ALDH1A1 | |
| SCHEMBL339635 | 0.86 | AR (0.38) | CYP1A2CYP3A4CYP2D6NPSR1ALDH1A1 | |
| SCHEMBL1911451 | 0.85 | HTT (0.45) | HTTCYP1A2CYP3A4CYP2D6NPSR1 | |
| SCHEMBL338779 | 0.84 | PIK3CB (0.38) | HTTALDH1A1CRHR1KDM4EMEN1 | |
| SCHEMBL338903 | 0.84 | CRHR1 (0.39) | CYP1A2CYP3A4CYP2D6NPSR1ALDH1A1 | |
| SCHEMBL1913165 | 0.83 | CRHR1 (0.42) | HTTCYP1A2CYP3A4CYP2D6NPSR1 | |
| SCHEMBL340129 | 0.82 | ALDH1A1 (0.39) | ALDH1A1CRHR1NPC1RAB9AAR | |
| SCHEMBL339127 | 0.81 | DPP4 (0.43) | CYP1A2CYP3A4CYP2D6NPSR1ALDH1A1 | |
| SCHEMBL339781 | 0.81 | ALDH1A1 (0.38) | HTTNPSR1ALDH1A1CRHR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077787-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2012-03-29 | — | — | US | disclosed |
| US-20120077787-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2012-03-29 | — | — | US | disclosed |
| US-20120077787-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2012-03-29 | — | — | US | disclosed |
| US-8097617-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-01-17 | — | — | US | disclosed |
| US-20090253689-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077787-A1 | ORGANIC COMPOUNDS | OAT, GPR119, OTC | HTT 3260/4885CYP1A2 260/4885CYP3A4 85/4885 |
| US-20090253689-A1 | Organic Compounds | OAT, GPR119, OTC | HTT 3260/4885CYP1A2 260/4885CYP3A4 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.