Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006371 | 0.85 | ALDH1A1 (0.41) | ALDH1A1TP53 | |
| SCHEMBL49441 | 0.78 | ALDH1A1 (0.47) | ALDH1A1TP53 | |
| SCHEMBL5847098 | 0.74 | ALDH1A1 (0.62) | ALDH1A1TP53 | |
| SCHEMBL623332 | 0.66 | — | — | |
| SCHEMBL1168085 | 0.64 | ALDH1A1 (0.59) | ALDH1A1TP53LMNA | |
| SCHEMBL3812521 | 0.64 | ALDH1A1 (0.38) | ALDH1A1TP53 | |
| SCHEMBL6744089 | 0.63 | NOS1 (0.31) | — | |
| SCHEMBL1819959 | 0.63 | — | — | |
| SCHEMBL6878279 | 0.63 | ALDH1A1 (0.38) | ALDH1A1LMNA | |
| SCHEMBL5551260 | 0.62 | ALDH1A1 (0.56) | ALDH1A1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240271119-A1 | METHODS OF PERIPLASMIC PHAGE-ASSISTED CONTINUOUS EVOLUTION | THE BROAD INSTITUTE, INC. (US) | 2024-08-15 | — | — | US | claimed |
| EP-3199630-B1 | CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS | HARVARD COLLEGE (US) | 2019-05-08 | — | — | EP | claimed |
| US-9771574-B2 | Apparatus for continuous directed evolution of proteins and nucleic acids | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-09-26 | — | — | US | claimed |
| EP-3199630-A1 | CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS | President and Fellows of Harvard College (US) | 2017-08-02 | — | — | EP | claimed |
| WO-2016077052-A9 | EVOLUTION OF PROTEASES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-07-21 | — | — | WO | claimed |
| WO-2016077052-A2 | EVOLUTION OF PROTEASES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-05-19 | — | — | WO | claimed |
| US-20150275202-A1 | CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-10-01 | — | — | US | claimed |
| US-9023594-B2 | Continuous directed evolution of proteins and nucleic acids | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-05-05 | — | — | US | claimed |
| WO-2010028347-A2 | CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS | PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) | 2010-03-11 | — | — | WO | claimed |
| US-12398390-B2 | Negative selection and stringency modulation in continuous evolution systems | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2025-08-26 | — | — | US | disclosed |
| US-12366009-B2 | Continuous directed evolution | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2025-07-22 | — | — | US | disclosed |
| US-20250195627-A1 | GTP CYCLOHYDROLASE-CLEAVING PROTEASES | THE BROAD INSTITUTE, INC. (US) | 2025-06-19 | — | — | US | disclosed |
| US-20250109177-A1 | EVOLVED PROTEIN DEGRONS | THE BROAD INSTITUTE, INC. (US) | 2025-04-03 | — | — | US | disclosed |
| US-20240287491-A1 | PROCASPASE-CLEAVING PROTEASES AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2024-08-29 | — | — | US | disclosed |
| US-9023594-B2 | Continuous directed evolution of proteins and nucleic acids | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-05-05 | — | — | US | disclosed |
| US-20130345064-A1 | CONTINUOUS DIRECTED EVOLUTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-12-26 | — | — | US | disclosed |
| WO-2010028347-A2 | CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS | PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2004084705-A2 | QUANTITATIVE DETECTION OF H. PYLORI IN BIOLOGICAL SAMPLES | UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES (US) | 2004-10-07 | — | — | WO | disclosed |
| US-4035568-A | Derivatives of polyene macrolide antibiotics | RUTGERS RESEARCH AND EDUCATIONAL FOUNDATION (US) | 1977-07-12 | — | — | US | disclosed |
| US-3945993-A | Derivatives of polyene macrolide antibiotics | RUTGERS RESEARCH AND EDUCATIONAL FOUNDATION (US) | 1976-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250109177-A1 | EVOLVED PROTEIN DEGRONS | SRP72, TIA1, SMURF1 | ALDH1A1 4776/4885TP53 5/4885LMNA 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.