Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DTYMK | P23919 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184876 | 0.84 | KDM4E (0.62) | KDM4EGLAALDH1A1MEN1MAPT | |
| SCHEMBL10527436 | 0.83 | ATM (0.43) | TSHRALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL6535043 | 0.83 | TSHR (0.47) | TSHRKDM4EGLAPTPN1ALDH1A1 | |
| SCHEMBL10361781 | 0.78 | TSHR (0.50) | TSHRKDM4EGLAPTPN1ALDH1A1 | |
| SCHEMBL4609556 | 0.77 | TSHR (0.54) | TSHRKDM4EGLAALDH1A1MEN1 | |
| SCHEMBL8034169 | 0.76 | PTPN1 (0.50) | TSHRPTPN1ALDH1A1MEN1KMT2A | |
| Trimethylammonium SCHEMBL28659606 | 0.76 | TSHR (0.64) | TSHRKDM4EGLAALDH1A1MEN1 | |
| SCHEMBL28600471 | 0.75 | ALDH1A1 (0.53) | TSHRKDM4EGLAPTPN1ALDH1A1 | |
| SCHEMBL29696138 | 0.75 | TSHR (0.67) | TSHRKDM4EALDH1A1MEN1GAA | |
| SCHEMBL30727560 | 0.75 | TSHR (0.67) | TSHRKDM4EALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12480111-B2 | Penicillin-G acylases | CODEXIS, INC. (US) | 2025-11-25 | — | — | US | disclosed |
| US-20250346882-A1 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2025-11-13 | — | — | US | disclosed |
| US-12378541-B2 | Penicillin-G acylases | CODEXIS, INC. (US) | 2025-08-05 | — | — | US | disclosed |
| US-20250034543-A1 | PENICILLIN-G ACYLASES | CODEXIS INC (US) | 2025-01-30 | — | — | US | disclosed |
| US-20240409916-A1 | PENICILLIN-G ACYLASES | CODEXIS INC (US) | 2024-12-12 | — | — | US | disclosed |
| US-12084697-B2 | Penicillin-G acylases | CODEXIS, INC. (US) | 2024-09-10 | — | — | US | disclosed |
| US-11965192-B2 | Penicillin-G acylases | CODEXIS, INC. (US) | 2024-04-23 | — | — | US | disclosed |
| US-20230272363-A1 | PENICILLIN-G ACYLASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-08-31 | — | — | US | disclosed |
| US-20230227805-A1 | PENICILLIN-G ACYLASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-07-20 | — | — | US | disclosed |
| US-11643642-B2 | Penicillin-g acylases | CODEXIS, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| EP-3292136-A1 | PENICILLIN-G ACYLASES | Codexis, Inc. (US) | 2018-03-14 | — | — | EP | disclosed |
| WO-2017193022-A1 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| US-20170321202-A1 | PENICILLIN-G ACYLASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2017-11-09 | — | — | US | disclosed |
| WO-2016179464-A1 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2016-11-10 | — | — | WO | disclosed |
| US-20160326508-A1 | PENICILLIN-G ACYLASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2016-11-10 | — | — | US | disclosed |
| US-8569013-B2 | Penicillin-G acylases | CODEXIS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120270282-A1 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-8247192-B2 | Penicillin-G acylases | CODEXIS, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20100143968-A1 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| WO-2010054319-A2 | PENICILLIN-G ACYLASES | CODEXIS, INC. (US) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270282-A1 | PENICILLIN-G ACYLASES | PGLS, PNP, NAAA | TSHR 4126/4885KDM4E 1645/4885GLA 101/4885 |
| US-20250034543-A1 | PENICILLIN-G ACYLASES | NAAA, PGLS, PNP | TSHR 4074/4885KDM4E 1547/4885GLA 94/4885 |
| US-20240409916-A1 | PENICILLIN-G ACYLASES | NAAA, PGLS, PNP | TSHR 3862/4885KDM4E 1732/4885GLA 89/4885 |
| US-11965192-B2 | Penicillin-G acylases | NAAA, PGLS, PNP | TSHR 4074/4885KDM4E 1547/4885GLA 94/4885 |
| US-12084697-B2 | Penicillin-G acylases | NAAA, PGLS, PNP | TSHR 3862/4885KDM4E 1732/4885GLA 89/4885 |
| US-20100143968-A1 | PENICILLIN-G ACYLASES | PGLS, PNP, NAAA | TSHR 4126/4885KDM4E 1645/4885GLA 101/4885 |
| US-20230227805-A1 | PENICILLIN-G ACYLASES | NAAA, PGLS, PNP | TSHR 3862/4885KDM4E 1732/4885GLA 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.