Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | C1S | P09871 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395887 | 0.84 | MAOB (0.46) | MAOBMRGPRX4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2431860 | 0.81 | MAOB (0.60) | MAOBMRGPRX4RAB9AALDH1A1GRM4 | |
| SCHEMBL8865210 | 0.79 | C1S (0.56) | NPC1SMN1; SMN2ALDH1A1TP53KMT2A | |
| SCHEMBL2278961 | 0.79 | CES2 (0.53) | MAOBNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2281706 | 0.75 | RAB9A (0.45) | MAOBNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2284121 | 0.75 | MAOB (0.47) | MAOBMRGPRX4NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1744811 | 0.74 | C1S (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL12251468 | 0.72 | LMNA (0.54) | MAOBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2277164 | 0.72 | TDP1 (0.45) | MAOBMRGPRX4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2283828 | 0.71 | CTSL (0.49) | SMN1; SMN2ALDH1A1TP53KMT2AC1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |