Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393541 | 0.89 | CACNA1B (0.56) | NAMPTSMN1; SMN2ALDH1A1KDM4ETDP1 | |
| SCHEMBL3395748 | 0.84 | HDAC3 (0.50) | NAMPTSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL3398555 | 0.84 | RAB9A (0.55) | NAMPTSMN1; SMN2ALDH1A1KDM4ETDP1 | |
| SCHEMBL3397270 | 0.83 | PTPN11 (0.50) | RAB9ANPC1KMT2APOLBHDAC3 | |
| SCHEMBL3398551 | 0.83 | POLB (0.49) | SMN1; SMN2ALDH1A1KDM4ETDP1RAB9A | |
| SCHEMBL3393588 | 0.81 | CSNK2A2 (0.55) | SMN1; SMN2ALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL3392289 | 0.81 | TRPV1 (0.49) | NAMPTSMN1; SMN2ALDH1A1MAPK1HDAC3 | |
| SCHEMBL3393246 | 0.81 | FLT3 (0.54) | NAMPTRAB9ANPC1KMT2APOLB | |
| SCHEMBL3393245 | 0.79 | TNIK (0.70) | SMN1; SMN2ALDH1A1KDM4ETDP1POLB | |
| SCHEMBL49506 | 0.74 | RAB9A (0.65) | NAMPTALDH1A1KDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216795-A1 | TNIK INHIBITOR AND THE USE | YAMADA TESSHI | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216795-A1 | TNIK INHIBITOR AND THE USE | TNIK, TNNI3K, TNK1 | NAMPT 1035/4885SMN1; SMN2 2662/4885ALDH1A1 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.