Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | TYR | P14679 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL6839186 | 1.00 | TSHR (0.67) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL2166865 | 1.00 | TSHR (0.67) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL21810513 | 0.97 | TSHR (0.63) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL6389843 | 0.97 | TSHR (0.63) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL11878692 | 0.97 | TSHR (0.63) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL27842952 | 0.95 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL2778330 | 0.95 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL1478940 | 0.94 | TSHR (0.67) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL21642976 | 0.94 | TSHR (0.67) | TSHRTP53SRD5A2CA1CA2 | |
| Paraben SCHEMBL2880234 | 0.91 | CA2 (0.73) | TSHRTP53SRD5A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 273 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110546182-B | Aliphatic thermoplastic polyurethanes, their preparation and use | 科思创德国股份有限公司 | 2022-02-15 | — | — | CN | claimed |
| EP-3612580-B1 | ALIPHATIC THERMOPLASTIC POLYURETHANES, THEIR PREPARATION AND USE | COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG (DE) | 2021-03-17 | — | — | EP | claimed |
| EP-3612580-A1 | ALIPHATIC THERMOPLASTIC POLYURETHANES, PRODUCTION AND USE THEREOF | Covestro Deutschland AG (DE) | 2020-02-26 | — | — | EP | claimed |
| US-20200040128-A1 | ALIPHATIC THERMOPLASTIC POLYURETHANES, PRODUCTION AND USE THEREOF | COVESTRO DEUTSCHLAND AG (DE) | 2020-02-06 | — | — | US | claimed |
| CN-110546182-A | aliphatic thermoplastic polyurethanes, their preparation and use | COVESTRO DEUTSCHLAND AG | 2019-12-06 | — | — | CN | claimed |
| EP-2758444-B1 | THERMOPLASTIC POLYURETHANE FOR PRODUCING HYDROPHILIC FIBERS | COVESTRO DEUTSCHLAND AG (DE) | 2018-01-24 | — | — | EP | claimed |
| US-9593199-B2 | Production and use of new thermoplastic polyurethane elastomers based on polyether carbonate polyols | COVESTRO DEUTSCHLAND AG (DE) | 2017-03-14 | — | — | US | claimed |
| US-20140350206-A1 | THERMOPLASTIC POLYURETHANE FOR PRODUCING HYDROPHILIC FIBERS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-11-27 | — | — | US | claimed |
| EP-1674494-B1 | Aliphatic sinterable thermoplastic polyurethanes and their use | BAYER MATERIALSCIENCE AG (DE) | 2008-03-05 | — | — | EP | claimed |
| US-20060142531-A1 | Aliphatic sinterable thermoplastic polyurethanes and use thereof | BAYER MATERIALSCIENCE AG | 2006-06-29 | — | — | US | claimed |
| US-6780957-B1 | HYDROPHOBIC POLYURETHANE ELASTOMER PREPARED BY COMBINING A POLYBUTADIENE DIOL AND AN ALIPHATIC OR CYCLOALIPHATIC DIISOCYANATE TO FORM AN ISOCYANATE TERMINATED PREPOLYMER AND CHAIN EXTENDING THE PREPOLYMER WITH A DIOL | BAYER POLYMERS LLC | 2004-08-24 | — | — | US | claimed |
| EP-1252213-A1 | HYDROPHOBIC LIGHT STABLE POLYURETHANE ELASTOMER WITH IMPROVED MECHANICAL PROPERTIES | Bayer Corporation (US) | 2002-10-30 | — | — | EP | claimed |
| WO-2001048046-A1 | HYDROPHOBIC LIGHT STABLE POLYURETHANE ELASTOMER WITH IMPROVED MECHANICAL PROPERTIES | BAYER CORPORATION (US) | 2001-07-05 | — | — | WO | claimed |
| US-5908894-A | CROSSLINKING; BLEND CONTAINING CHAIN EXTENDERS, CATALYST; COMMINUTED FORM | BASF AKTIENGESELLSCHAFT (DE) | 1999-06-01 | — | — | US | claimed |
| US-12576625-B2 | Layer structure for producing a hinge, in particular for producing multi-layered book covers | COVESTRO DEUTSCHLAND AG (DE) | 2026-03-17 | — | — | US | disclosed |
| US-12479966-B2 | Method for producing thermoplastic polyurethanes | COVESTRO DEUTSCHLAND AG (DE) | 2025-11-25 | — | — | US | disclosed |
| US-12194768-B2 | Layer structure with engraving as visible security element | COVESTRO DEUTSCHLAND AG (DE) | 2025-01-14 | — | — | US | disclosed |
| US-4692373-A | Laminate bonded by adhesion promoting layer and adhesive layer | BASF AKTIENGESELLSCHAFT (DE) | 1987-09-08 | — | — | US | disclosed |
| US-4191818-A | Process for preparing heat-resistant polyurethane elastomers having no secondary softening range | BASF WYANDOTTE CORPORATION (US) | 1980-03-04 | — | — | US | disclosed |
| US-4098773-A | ADDUCTS | BASF WYANDOTTE CORPORATION (US) | 1978-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12576625-B2 | Layer structure for producing a hinge, in particular for producing multi-layered book covers | SMCHD1, DSG1, DSP | TSHR 4485/4885TP53 1826/4885SRD5A2 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.