Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394251 | 0.96 | PTK2B (0.39) | MAPTMAPK1LMNAKMT2AMEN1 | |
| SCHEMBL3390908 | 0.93 | ALDH1A1 (0.38) | MAPTMAPK1KMT2AALDH1A1PTK2B | |
| SCHEMBL3394286 | 0.93 | LMNA (0.37) | MAPTMAPK1LMNAKMT2AMEN1 | |
| SCHEMBL3389398 | 0.90 | PTK2B (0.36) | MAPTMAPK1LMNAKMT2AMEN1 | |
| SCHEMBL3394297 | 0.90 | PTK2B (0.40) | LMNAKMT2AHTTALDH1A1KDM4E | |
| SCHEMBL3392512 | 0.90 | PTK2B (0.36) | MAPTKMT2AMEN1PTK2BMAPK14 | |
| SCHEMBL3389419 | 0.89 | ALDH1A1 (0.39) | MAPTLMNAKMT2AMEN1TSHR | |
| SCHEMBL3180430 | 0.88 | CDK8 (0.35) | PTK2BMAPK14 | |
| SCHEMBL3392554 | 0.88 | PTK2B (0.37) | KMT2AMEN1TSHRPOLBHTT | |
| SCHEMBL3393200 | 0.88 | PTK2B (0.37) | MAPTMAPK1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |