Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394297 | 0.93 | PTK2B (0.40) | KMT2AKDM4EPTK2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL3393200 | 0.93 | PTK2B (0.37) | NPY2RKMT2AMEN1PTK2BPOLB | |
| SCHEMBL3392554 | 0.92 | PTK2B (0.37) | KMT2AMEN1KDM4EPTK2BPOLB | |
| SCHEMBL3394251 | 0.91 | PTK2B (0.39) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3390908 | 0.91 | ALDH1A1 (0.38) | NPY2RKMT2AABL1BCRPTK2B | |
| SCHEMBL3389398 | 0.90 | PTK2B (0.36) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3394286 | 0.89 | LMNA (0.37) | TP53KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL3392512 | 0.89 | PTK2B (0.36) | TP53KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL3391110 | 0.89 | GBA1 (0.41) | NPY2R | |
| SCHEMBL3174404 | 0.89 | MAPK14 (0.38) | PTK2BALDH1A1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |