Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5494092 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1TSHRTDP1LMNA | |
| SCHEMBL17934362 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1TSHRTDP1LMNA | |
| SCHEMBL27553613 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1TSHRTDP1LMNA | |
| SCHEMBL3880455 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1TSHRTDP1LMNA | |
| SCHEMBL154141 | 0.75 | — | — | |
| SCHEMBL4445948 | 0.74 | KDM4E (0.48) | KDM4EALDH1A1TSHRTDP1LMNA | |
| SCHEMBL1012047 | 0.74 | KDM4E (0.48) | KDM4EALDH1A1TSHRTDP1LMNA | |
| SCHEMBL7129959 | 0.74 | KDM4E (0.42) | KDM4EALDH1A1TSHRTDP1LMNA | |
| SCHEMBL14857811 | 0.70 | — | — | |
| SCHEMBL11713670 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119181-A1 | Hydrophobically-modified protein compositions and methods | BIOGEN IDEC INC. (US) | 2005-06-02 | — | — | US | claimed |
| EP-1036092-B1 | Hydrophobically-modified hedgehog protein compositions and methods | BIOGEN INC (US) | 2005-05-11 | — | — | EP | claimed |
| EP-1036092-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 2000-09-20 | — | — | EP | claimed |
| WO-1999028343-A9 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN INC (US) | 1999-10-14 | — | — | WO | claimed |
| WO-1999028343-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 1999-06-10 | — | — | WO | claimed |
| EP-1646395-B1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | CURIS INC (US) | 2014-11-05 | — | — | EP | disclosed |
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-04-04 | — | — | US | disclosed |
| US-20120269863-A1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | CURIS, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120238500-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-8168178-B2 | Methods and compositions for regulating lymphocyte activity | CURIS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8097253-B2 | Methods for inhibiting angiogenesis | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-01-17 | — | — | US | disclosed |
| US-20110124580-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-05-26 | — | — | US | disclosed |
| WO-2000027422-A2 | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PERIPHERAL NEUROPATHIES | BIOGEN, INC. (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000015246-A2 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999028343-A9 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN INC (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999028343-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 1999-06-10 | — | — | WO | disclosed |
| WO-1999020298-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999010004-A2 | REGULATION OF MUSCLE TISSUES BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 1999-03-04 | — | — | WO | disclosed |
| US-5801274-A | N- mercaptoacyl(amino acid or peptide)! compounds and S-lipophilic aliphatic carbonyl derivatives thereof as antihypertensives | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-09-01 | — | — | US | disclosed |
| US-5591891-A | PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238500-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, SMO, GLI1 | KDM4E 4038/4885ALDH1A1 3638/4885TSHR 1439/4885 |
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, FGF1, HGF | KDM4E 4223/4885ALDH1A1 2474/4885TSHR 309/4885 |
| US-20110124580-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, FGF1, HGF | KDM4E 4182/4885ALDH1A1 2489/4885TSHR 311/4885 |
| US-20120269863-A1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | SHH, ICOS, SMO | KDM4E 2194/4885ALDH1A1 4111/4885TSHR 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.