Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3552683 | 0.81 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL3563925 | 0.77 | PTGS2 (0.40) | PTGS2KDM4EALDH1A1LMNA | |
| SCHEMBL3810142 | 0.75 | PTGS2 (0.40) | PTGS2 | |
| SCHEMBL3564109 | 0.75 | MMP2 (0.40) | PTGS2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL3394581 | 0.71 | PTGS2 (0.58) | PTGS2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL3560853 | 0.70 | LMNA (0.43) | PTGS2NPC1ALDH1A1LMNAGAA | |
| SCHEMBL12002628 | 0.70 | IDO1 (0.46) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL3555649 | 0.68 | PTGS2 (0.34) | PTGS2PTGS1 | |
| SCHEMBL481257 | 0.67 | IDO1 (0.50) | KDM4ENPC1ALDH1A1LMNAHPGD | |
| SCHEMBL12002955 | 0.67 | PPARA (0.35) | NPC1TSHRRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |