Sugi Predict

Sugi Predict / Compounds / SCHEMBL339518

SCHEMBL339518

SCHEMBL339518

CC(=O)C1CCCC2CCCCC21

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ EPHX1 P07099 1/20 0.35
▸ CYP2D6 P10635 2/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ CYP1A2 P05177 1/20 0.32
▸ HSD11B1 P28845 1/20 0.31
▸ HSD11B2 P80365 1/20 0.31
▸ PSEN1 P49768 3/20 0.31
▸ PSEN2 P49810 3/20 0.31
▸ APH1B Q8WW43 3/20 0.31
▸ NCSTN Q92542 3/20 0.31
▸ APH1A Q96BI3 3/20 0.31
▸ PSENEN Q9NZ42 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7247031 1.00 EPHX1 (0.35) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL4610992 1.00 EPHX1 (0.35) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL29107738 0.95 EPHX1 (0.35) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL13433450 0.95 EPHX1 (0.35) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL13433447 0.95 EPHX1 (0.35) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL29107877 0.95 EPHX1 (0.35) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL23109104 0.91 HSD11B1 (0.35) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL13328489 0.91 HSD11B1 (0.35) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL6831574 0.88 MEN1 (0.33) EPHX1CYP2D6ALDH1A1MEN1KMT2A
SCHEMBL20614627 0.86 HSD11B1 (0.35) EPHX1ALDH1A1HSD11B1HSD11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050119181-A1 Hydrophobically-modified protein compositions and methods BIOGEN IDEC INC. (US) 2005-06-02 — — US claimed
EP-1036092-B1 Hydrophobically-modified hedgehog protein compositions and methods BIOGEN INC (US) 2005-05-11 — — EP claimed
EP-1036092-A2 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS BIOGEN, INC. (US) 2000-09-20 — — EP claimed
WO-1999028343-A9 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS BIOGEN INC (US) 1999-10-14 — — WO claimed
WO-1999028343-A2 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS BIOGEN, INC. (US) 1999-06-10 — — WO claimed
JP-5178782-A — — None — — JP disclosed
EP-1646395-B1 METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY CURIS INC (US) 2014-11-05 — — EP disclosed
US-20130085096-A1 REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2013-04-04 — — US disclosed
US-20120269863-A1 METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY CURIS, INC. (US) 2012-10-25 — — US disclosed
US-20120238500-A1 REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO CURIS, INC. (US) 2012-09-20 — — US disclosed
US-8168178-B2 Methods and compositions for regulating lymphocyte activity CURIS, INC. (US) 2012-05-01 — — US disclosed
US-8097253-B2 Methods for inhibiting angiogenesis UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2012-01-17 — — US disclosed
WO-1999028343-A9 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS BIOGEN INC (US) 1999-10-14 — — WO disclosed
WO-1999028343-A2 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS BIOGEN, INC. (US) 1999-06-10 — — WO disclosed
WO-1999020298-A1 REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO ONTOGENY, INC. (US) 1999-04-29 — — WO disclosed
WO-1999010004-A2 REGULATION OF MUSCLE TISSUES BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO ONTOGENY, INC. (US) 1999-03-04 — — WO disclosed
US-5801274-A N- mercaptoacyl(amino acid or peptide)! compounds and S-lipophilic aliphatic carbonyl derivatives thereof as antihypertensives INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 1998-09-01 — — US disclosed
US-5591891-A PEPTIDASE INHIBITORS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1997-01-07 — — US disclosed
WO-1994017036-A1 S-LIPOPHILIC ALIPHATIC CARBONYL [N-MERCAPTOACYL-(AMINO ACID OR PEPTIDE)] COMPOUNDS AS ANTIHYPERTENSIVE AGENTS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1994-08-04 — — WO disclosed
JP-H05178782-A PREPARATION OF 2-VINYLNAPHTHALENE HOECHST CELANESE CORP 1993-07-20 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120238500-A1 REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO SHH, SMO, GLI1 EPHX1 1809/4885CYP2D6 4882/4885ALDH1A1 3638/4885
US-20130085096-A1 REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO SHH, FGF1, HGF EPHX1 1796/4885CYP2D6 4882/4885ALDH1A1 2474/4885
US-20120269863-A1 METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY SHH, ICOS, SMO EPHX1 977/4885CYP2D6 4299/4885ALDH1A1 4111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.