Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 7/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301761 | 0.86 | ADRA1A (0.60) | ADRA1AADRA1BADRA1DHTR1A | |
| SCHEMBL3955000 | 0.84 | ADRA1D (0.58) | ADRA1AADRA1BADRA1DHTR1A | |
| SCHEMBL3954997 | 0.84 | ADRA1D (0.58) | ADRA1AADRA1BADRA1DHTR1A | |
| SCHEMBL3400411 | 0.84 | DRD2 (0.59) | ADRA1AADRA1BADRA1DHTR1A | |
| SCHEMBL3401668 | 0.83 | DRD2 (0.63) | ADRA1AADRA1BADRA1DHTR1A | |
| SCHEMBL14621895 | 0.80 | DRD2 (0.67) | ADRA1AADRA1BADRA1DHTR1A | |
| SCHEMBL3402455 | 0.79 | DRD2 (0.62) | ADRA1AADRA1BADRA1D | |
| SCHEMBL14984402 | 0.77 | HTR6 (0.60) | ADRA1AADRA1BADRA1DHTR1A | |
| SCHEMBL8758360 | 0.76 | ADRA1D (0.64) | ADRA1AADRA1BADRA1DHTR1A | |
| SCHEMBL3399759 | 0.76 | DRD2 (0.71) | ADRA1AADRA1BADRA1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156822-B2 | Functionally selective ligands of dopamine D2 receptors | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2015-10-13 | — | — | US | disclosed |
| US-20130137679-A1 | Novel Functionally Selective Ligands of Dopamine D2 Receptors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-05-30 | — | — | US | disclosed |
| WO-2012003418-A2 | FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137679-A1 | Novel Functionally Selective Ligands of Dopamine D2 Receptors | DRD2, AVPR2, NTSR2 | ADRA1A 113/4885ADRA1B 108/4885ADRA1D 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.