Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | FER | P16591 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | MARK3 | P27448 | 2/20 | 0.31 |
| ▸ | FLT4 | P35916 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | CLK2 | P49760 | 2/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9649202 | 0.80 | MEN1 (0.35) | ALDH1A1 | |
| SCHEMBL9145858 | 0.73 | — | — | |
| SCHEMBL11705130 | 0.70 | ALDH1A1 (0.44) | ALDH1A1MAPK1CRHBPCRHR2TDP1 | |
| SCHEMBL5100729 | 0.68 | BACE1 (0.39) | ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27959056 | 0.66 | ALDH1A1 (0.48) | ALDH1A1MAPK1CRHBPCRHR2TDP1 | |
| SCHEMBL28033901 | 0.65 | ALDH1A1 (0.48) | ALDH1A1MAPK1CRHBPCRHR2TDP1 | |
| SCHEMBL458135 | 0.65 | CYP2A6 (0.44) | ALDH1A1TDP1NQO2 | |
| SCHEMBL743835 | 0.64 | — | — | |
| SCHEMBL5085470 | 0.64 | RAB9A (0.37) | ALDH1A1MAPK1NPC1TP53TSHR | |
| SCHEMBL7702034 | 0.64 | CYP1A2 (0.41) | ALDH1A1NPC1TP53TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674909-B2 | Biphenyl-4-carboxylic acid {1-acetyl-4-[4-(2-dimethylammo-ethoxy-phenyl]-2,2,4-trimethyl-1,2,3,4-tetrahydro-quinolin-6-yl}-amide; fertility regulation; follicle stimulating hormone (FSH) | N.V. ORGANON (NL) | 2010-03-09 | — | — | US | disclosed |
| US-20060167047-A1 | Tetrahydorquinoline derivatives and their use as fsh receptor modulators | MERCK SHARP & DOHME B.V. (NL) | 2006-07-27 | — | — | US | disclosed |
| EP-1242399-A1 | $g(a)-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS | UCB S.A. (BE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046167-A1 | α-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS | UCB, S.A. (BE) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167047-A1 | Tetrahydorquinoline derivatives and their use as fsh receptor modulators | FSHR, GNRHR, LHCGR | ALDH1A1 2019/4885MAPK1 3059/4885CRHBP 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.