SCHEMBL7702034

SCHEMBL7702034

Clc1c[c]c(-c2ccccc2)c(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.41
CYP2A6 P11509 1/20 0.38
NPSR1 Q6W5P4 2/20 0.37
KDM4E B2RXH2 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
ESR2 Q92731 1/20 0.36
TSHR P16473 4/20 0.36
ALDH1A1 P00352 4/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
TP53 P04637 3/20 0.36
HPGD P15428 2/20 0.36
HSD17B10 Q99714 1/20 0.36
AKR1C2 P52895 1/20 0.35
AKR1C1 Q04828 1/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HSD11B1 P28845 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6081036 0.84 AHR (0.43) CYP1A2CYP2A6KDM4ETSHRALDH1A1
SCHEMBL7509509 0.83 ALOX5 (0.41) KDM4EESR2TSHRALDH1A1SMN1; SMN2
SCHEMBL16719843 0.82 ESR2 (0.41) CYP1A2CYP2A6KDM4EESR2ALDH1A1
SCHEMBL7566027 0.79 NPC1 (0.39) KDM4ETSHRALDH1A1SMN1; SMN2NPC1
SCHEMBL9646653 0.79 GABRA1 (0.36) CYP1A2RXFP1TSHRALDH1A1SMN1; SMN2
SCHEMBL9646878 0.79 TAAR1 (0.39) KDM4EESR2ALDH1A1MEN1KMT2A
SCHEMBL28328972 0.77 AKR1C2 (0.33) CYP2A6ESR2ALDH1A1HPGDAKR1C2
SCHEMBL3018345 0.77 AHR (0.52) KDM4ETSHRALDH1A1NPC1RAB9A
SCHEMBL14975559 0.77 CYP2A6 (0.41) CYP2A6KDM4ETSHRALDH1A1SMN1; SMN2
SCHEMBL9529033 0.75 MAOA (0.39) CYP2A6KDM4ETSHRALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2782565-A1 USE OF ARYL AND HETARYL CARBOXAMIDES AS ENDOPARASITICIDES Bayer Intellectual Property GmbH (DE) 2014-10-01 EP disclosed
WO-2013076230-A1 USE OF ARYL AND HETARYL CARBOXAMIDES AS ENDOPARASITICIDES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-05-30 WO disclosed
EP-1242399-A1 $g(a)-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS UCB S.A. (BE) 2002-09-25 EP disclosed
WO-2001046167-A1 α-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS UCB, S.A. (BE) 2001-06-28 WO disclosed
EP-0283041-B1 DIRECT POSITIVE SILVER HALIDE PHOTOSENSITIVE MATERIAL AND METHOD FOR FORMING DIRECT POSITIVE IMAGE FUJI PHOTO FILM CO., LTD. (JP) 1992-10-07 EP disclosed
US-4952483-A NOVEL HYDRAZINE NUCLEATING AGENTS AND ACCELERATORS FUJI PHOTO FILM CO., LTD. (JP) 1990-08-28 US disclosed
EP-0283041-A1 Direct positive silver halide photosensitive material and method for forming direct positive image FUJI PHOTO FILM CO., LTD. (JP) 1988-09-21 EP disclosed