SCHEMBL3397017

SCHEMBL3397017

O=C(O)n1nc(-c2ccc(F)cc2Br)cc1CBr

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.37
HDAC3 O15379 3/20 0.32
HDAC4 P56524 3/20 0.32
HDAC1 Q13547 3/20 0.32
HDAC7 Q8WUI4 3/20 0.32
HDAC2 Q92769 3/20 0.32
HDAC10 Q969S8 3/20 0.32
HDAC11 Q96DB2 3/20 0.32
HDAC8 Q9BY41 3/20 0.32
HDAC6 Q9UBN7 3/20 0.32
HDAC9 Q9UKV0 3/20 0.32
HDAC5 Q9UQL6 3/20 0.32
NCOR2 Q9Y618 3/20 0.32
KMO O15229 2/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
RIPK1 Q13546 1/20 0.30
ALPL P05186 1/20 0.30
FABP3 P05413 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3431052 0.86 CNR1 (0.37) FABP3KDM4E
SCHEMBL13425802 0.82 MKNK1 (0.34) PKM
SCHEMBL3395630 0.81 HDAC6 (0.44) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3397709 0.77 GRM5 (0.41) NPC1
SCHEMBL3394902 0.69 GSK3B (0.39)
SCHEMBL13425453 0.68 PDE4B (0.35) PKMHDAC1HDAC2
SCHEMBL3395758 0.68 GRK6 (0.41) RAB9A
SCHEMBL3390188 0.67 F11 (0.42)
SCHEMBL29462675 0.63 PKM (0.39) PKMNPC1RAB9A
SCHEMBL15213955 0.63 PKM (0.39) PKMNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed