Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.33 |
| ▸ | CLK1 | P49759 | 3/20 | 0.33 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392201 | 0.84 | SLC6A4 (0.38) | SLC6A4PIM1PIM2PRMT6MEN1 | |
| SCHEMBL3395465 | 0.81 | SLC6A4 (0.47) | SLC6A4PRMT6CETPLSSACHE | |
| SCHEMBL3398483 | 0.77 | ERCC5 (0.39) | SLC6A4PRMT6HDAC6CETPABL1 | |
| SCHEMBL13074386 | 0.73 | SLC6A4 (0.57) | SLC6A4PRMT6CETPLSSACHE | |
| SCHEMBL3708151 | 0.72 | PIM1 (0.39) | PIM1PIM2PRMT6HDAC6ACHE | |
| Hydrochloric Acid SCHEMBL3394496 | 0.72 | PIM1 (0.38) | PIM1PIM2PRMT6HDAC6ACHE | |
| SCHEMBL3395850 | 0.71 | PRMT1 (0.59) | SLC6A4PIM1PRMT6LSSACHE | |
| SCHEMBL29953766 | 0.67 | CA1 (0.52) | PIM1KMT2AABL1SLC6A3 | |
| SCHEMBL2644779 | 0.67 | CA1 (0.52) | PIM1KMT2AABL1SLC6A3 | |
| SCHEMBL12777905 | 0.67 | NPC1 (0.43) | PIM1KMT2AHDAC6DYRK1ACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |