Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | LPL | P06858 | 2/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13074386 | 0.87 | SLC6A4 (0.57) | SLC6A4PRMT6ALDH1A1TSHRSLC6A3 | |
| SCHEMBL3395850 | 0.85 | PRMT1 (0.59) | SLC6A4PRMT6TSHRLSSACHE | |
| SCHEMBL3398483 | 0.85 | ERCC5 (0.39) | SLC6A4PRMT6ALDH1A1SLC6A3LSS | |
| SCHEMBL147828 | 0.82 | CA2 (0.52) | LPLLIPGTSHRGRIN2BCA1 | |
| SCHEMBL3397309 | 0.81 | SLC6A4 (0.36) | SLC6A4PRMT6ALDH1A1SLC6A3LSS | |
| SCHEMBL13070333 | 0.80 | SLC6A4 (0.50) | SLC6A4PRMT6ALDH1A1TSHRSLC6A3 | |
| SCHEMBL3423840 | 0.80 | SLC6A4 (0.50) | SLC6A4PRMT6ALDH1A1TSHRSLC6A3 | |
| SCHEMBL9893608 | 0.78 | MMP1 (0.49) | LPLLIPGENPP2 | |
| SCHEMBL27233488 | 0.77 | CA2 (0.48) | LPLLIPGALDH1A1TSHRGRIN2B | |
| SCHEMBL19697830 | 0.77 | PYCR1 (0.51) | LPLLIPGCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |