Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402080 | 0.90 | ZAP70 (0.48) | ZAP70MAPTTSHRNR4A1CYP1B1 | |
| SCHEMBL3401682 | 0.84 | ZAP70 (0.44) | ZAP70MAPTTSHRNR4A1CYP1B1 | |
| SCHEMBL3405873 | 0.79 | ZAP70 (0.46) | ZAP70NTRK1MAPTCYP1B1CYP1A1 | |
| SCHEMBL3428156 | 0.76 | ZAP70 (0.45) | ZAP70NTRK1MAPTTSHRMEN1 | |
| SCHEMBL3397301 | 0.75 | MAPT (0.50) | ZAP70MAPTCYP1A2KDM4EMEN1 | |
| SCHEMBL3428992 | 0.74 | AURKA (0.49) | ZAP70MAPTMAPK1AURKASYK | |
| SCHEMBL1059320 | 0.74 | ZAP70 (0.59) | ZAP70NTRK1MAPTTSHRNR4A1 | |
| SCHEMBL3406123 | 0.71 | IGF1R (0.48) | ZAP70MAPTKDM4EMEN1MAPK1 | |
| SCHEMBL3394570 | 0.71 | ZAP70 (0.55) | ZAP70MAPTTSHRNR4A1CYP1B1 | |
| SCHEMBL1059382 | 0.71 | ZAP70 (0.55) | ZAP70NTRK1MAPTTSHRNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | claimed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | claimed |