Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.45 |
| ▸ | SYK | P43405 | 5/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405873 | 0.85 | ZAP70 (0.46) | ZAP70SYKBTKMAPTFLT3 | |
| SCHEMBL3402080 | 0.76 | ZAP70 (0.48) | ZAP70MAPTMEN1ALDH1A1TSHR | |
| SCHEMBL3401682 | 0.76 | ZAP70 (0.44) | ZAP70MAPTMEN1ALDH1A1TSHR | |
| SCHEMBL3397387 | 0.76 | ZAP70 (0.48) | ZAP70SYKMAPTMEN1TSHR | |
| SCHEMBL3397301 | 0.76 | MAPT (0.50) | ZAP70SYKMAPTNPC1RAB9A | |
| SCHEMBL1056532 | 0.75 | SYK (0.65) | ZAP70SYKBTKUSP2PIK3CA | |
| SCHEMBL3428992 | 0.75 | AURKA (0.49) | ZAP70SYKMAPTBRD4MAPK1 | |
| SCHEMBL3362020 | 0.72 | ZAP70 (0.46) | ZAP70SYKBTKMAPTFLT3 | |
| SCHEMBL3406123 | 0.72 | IGF1R (0.48) | ZAP70MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL12128810 | 0.70 | MAPT (0.62) | MAPTNPC1RAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | claimed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | claimed |