Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397301 | 0.92 | MAPT (0.50) | IGF1RMAPTLMNAMEN1KMT2A | |
| SCHEMBL3402080 | 0.79 | ZAP70 (0.48) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL3428992 | 0.77 | AURKA (0.49) | IGF1RMAPTTP53MAPK1BRD4 | |
| SCHEMBL3405873 | 0.77 | ZAP70 (0.46) | MAPTTP53JAK2JAK3MAPK1 | |
| SCHEMBL3401682 | 0.75 | ZAP70 (0.44) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL1059680 | 0.73 | SRC (0.52) | IGF1RMAPTLMNAMEN1KMT2A | |
| SCHEMBL3428156 | 0.72 | ZAP70 (0.45) | MAPTMEN1KMT2AJAK2ALDH1A1 | |
| SCHEMBL3397387 | 0.71 | ZAP70 (0.48) | MAPTMEN1KMT2AMAPK1PKMYT1 | |
| SCHEMBL12617253 | 0.69 | CHEK1 (0.59) | IGF1RMAPTLMNAMEN1KMT2A | |
| SCHEMBL14355350 | 0.69 | MAPT (0.56) | IGF1RMAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | claimed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | claimed |