Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402080 | 0.88 | ZAP70 (0.48) | ZAP70CYP1B1CYP1A2ALOX5MAPT | |
| SCHEMBL3397387 | 0.84 | ZAP70 (0.48) | ZAP70CYP1B1CYP1A2ALOX5MAPT | |
| SCHEMBL3405873 | 0.81 | ZAP70 (0.46) | ZAP70CYP1B1CYP1A2ALOX5MAPT | |
| SCHEMBL3397301 | 0.79 | MAPT (0.50) | ZAP70CYP1A2MAPTMAPK1TP53 | |
| SCHEMBL3428156 | 0.76 | ZAP70 (0.45) | ZAP70ALOX5MAPTMAPK1GAA | |
| SCHEMBL3428992 | 0.76 | AURKA (0.49) | ZAP70MAPTMAPK1TP53NPSR1 | |
| SCHEMBL3406123 | 0.75 | IGF1R (0.48) | ZAP70MAPTMAPK1TP53GAA | |
| SCHEMBL1059221 | 0.74 | SYK (0.57) | ZAP70MAPTGAALMNAMEN1 | |
| SCHEMBL3394570 | 0.69 | ZAP70 (0.55) | ZAP70CYP1B1MAPTMAPK1GAA | |
| SCHEMBL3359711 | 0.66 | MAPT (0.42) | ZAP70CYP1B1CYP1A2ALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | claimed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | claimed |