Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 8/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397301 | 0.81 | MAPT (0.50) | AURKAZAP70TP53MAPTMAPK1 | |
| SCHEMBL3405873 | 0.80 | ZAP70 (0.46) | ZAP70TP53MAPTMAPK1NPSR1 | |
| SCHEMBL3406123 | 0.77 | IGF1R (0.48) | ZAP70TP53MAPTMAPK1BRD4 | |
| SCHEMBL3428862 | 0.77 | CTSC (0.50) | MAPTBRD4 | |
| SCHEMBL3401682 | 0.76 | ZAP70 (0.44) | AURKAZAP70TP53MAPTMAPK1 | |
| SCHEMBL3402080 | 0.76 | ZAP70 (0.48) | AURKAZAP70TP53MAPTMAPK1 | |
| SCHEMBL3428156 | 0.75 | ZAP70 (0.45) | ZAP70MAPTMAPK1BRD4SYK | |
| SCHEMBL3397387 | 0.74 | ZAP70 (0.48) | AURKAZAP70MAPTMAPK1SYK | |
| SCHEMBL1059836 | 0.71 | ZAP70 (0.60) | AURKAZAP70BRD4SYK | |
| SCHEMBL31163056 | 0.66 | BRD4 (0.76) | BRD4SYKALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | claimed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | claimed |