Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.61 |
| ▸ | IDO1 | P14902 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | LDHA | P00338 | 1/20 | 0.61 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ADH5 | P11766 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645793 | 0.76 | MEN1 (0.73) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL2645790 | 0.76 | ALDH1A1 (0.73) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL30153550 | 0.76 | MEN1 (0.80) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL8429622 | 0.76 | GAA (1.00) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL8294492 | 0.76 | ALDH1A1 (0.73) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL14262602 | 0.76 | MEN1 (0.73) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL14844440 | 0.76 | ALDH1A1 (0.73) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL4206359 | 0.76 | PBRM1 (1.00) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL8294486 | 0.76 | LDHA (1.00) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 | |
| SCHEMBL6472013 | 0.76 | IDO1 (1.00) | ALDH1A1MEN1KMT2AL3MBTL1PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246348-A1 | Coupling reactions useful in the preparation of (1h-tetrazol-5-yl)-biphenyl derivatives | Novartis AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| US-20100152458-A1 | COUPLING REACTIONS USEFUL IN THE PREPARATION OF (1H-TETRAZOL-5-YL) BIPHENYL DERIVATIVES | NOVARTIS PHARMACEUTICALS CORPORATION | 2010-06-17 | — | — | US | disclosed |
| US-7700784-B2 | Coupling reactions useful in the preparation of (1h-tetrazol-5-yl) biphenyl derivatives | NOVARTIS AG (CH) | 2010-04-20 | — | — | US | disclosed |
| CN-100528868-C | Coupling reactions useful in the preparation of (1h-tetrazol-5-yl)-biphenyl derivatives | NOVARTIS AG (CH) | 2009-08-19 | — | — | CN | disclosed |
| US-20070129413-A1 | Coupling reactions useful in the preparation of (1h-tetrazol-5-yl) biphenyl derivatives | NOVARTIS PHARMACEUTICALS CORPORATION | 2007-06-07 | — | — | US | disclosed |
| CN-1914197-A | Coupling reactions useful in the preparation of (1h-tetrazol-5-yl)-biphenyl derivatives | NOVARTIS AG (CH) | 2007-02-14 | — | — | CN | disclosed |
| EP-1716140-A1 | COUPLING REACTIONS USEFUL IN THE PREPARATION OF (1H-TETRAZOL-5-YL)-BIPHENYL DERIVATIVES | Novartis AG (CH) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005075462-A1 | COUPLING REACTIONS USEFUL IN THE PREPARATION OF (1H-TETRAZOL-5-YL)-BIPHENYL DERIVATIVES | NOVARTIS AG (CH) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152458-A1 | COUPLING REACTIONS USEFUL IN THE PREPARATION OF (1H-TETRAZOL-5-YL) BIPHENYL DERIVATIVES | AGTR1, AGTR2, AGT | ALDH1A1 633/4885MEN1 2390/4885KMT2A 2815/4885 |
| US-20070129413-A1 | Coupling reactions useful in the preparation of (1h-tetrazol-5-yl) biphenyl derivatives | AGTR1, AGTR2, AGT | ALDH1A1 1285/4885MEN1 2139/4885KMT2A 3213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.