Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 8/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 2/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994829 | 0.91 | ALDH1A1 (0.51) | ALDH1A1ALDH3A1BRD4PTGER4MEN1 | |
| SCHEMBL3995363 | 0.87 | BRD4 (0.55) | ALDH1A1ALDH3A1BRD4PTGER4 | |
| SCHEMBL3996701 | 0.85 | BRD4 (0.51) | ALDH1A1ALDH3A1BRD4PTGER4 | |
| SCHEMBL15068205 | 0.82 | ALDH1A1 (0.56) | ALDH1A1ALDH3A1BRD4PTGER4MEN1 | |
| SCHEMBL4000487 | 0.82 | GBA1 (0.47) | ALDH1A1ALDH3A1BRD4PTGER4 | |
| SCHEMBL3997818 | 0.82 | ALDH1A1 (0.53) | ALDH1A1ALDH3A1BRD4PTGER4MEN1 | |
| SCHEMBL2014382 | 0.80 | ALDH1A1 (0.53) | ALDH1A1ALDH3A1LRRK2G6PDIDE | |
| SCHEMBL3369999 | 0.79 | KMT2A (0.69) | ALDH1A1ALDH3A1BRD4MEN1KMT2A | |
| SCHEMBL3997147 | 0.79 | RORC (0.48) | ALDH1A1ALDH3A1BRD4PTGER4MEN1 | |
| SCHEMBL1700398 | 0.78 | BRD4 (0.48) | ALDH1A1ALDH3A1BRD4PTGER4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994011-B1 | SULFONYL BENZIMIDAZOLE DERIVATIVES | RAQUALIA PHARMA INC (JP) | 2010-10-13 | — | — | EP | disclosed |
| US-7700618-B2 | Sulfonyl benzimidazole derivatives | PFIZER INC (US) | 2010-04-20 | — | — | US | disclosed |
| US-7598393-B2 | Sulfonyl benzimidazole derivatives | PFIZER INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20090137584-A1 | SULFONYL BENZIMIDAZOLE DERIVATIVES | RAQUALIA PHARMA INC. (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1809607-B1 | SULFONYL BENZIMIDAZOLE DERIVATIVES | PFIZER (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20060094750-A1 | Sulfonyl benzimidazole derivatives | KON-I KANA | 2006-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137584-A1 | SULFONYL BENZIMIDAZOLE DERIVATIVES | TRPV1, CNR2, CNR1 | ALDH1A1 3471/4885ALDH3A1 3288/4885BRD4 211/4885 |
| US-20060094750-A1 | Sulfonyl benzimidazole derivatives | TRPV1, CNR2, CNR1 | ALDH1A1 2810/4885ALDH3A1 2944/4885BRD4 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.