Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | PLEC | Q15149 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10784621 | 0.84 | MAPT (0.52) | MAPTLMNAG6PDIDEPKM | |
| SCHEMBL2356286 | 0.81 | LMNA (0.78) | ALDH1A1MAPTGAAKDM4ETHRB | |
| SCHEMBL2253611 | 0.80 | G6PD (0.50) | ALDH1A1MAPTGAAG6PDIDE | |
| SCHEMBL29602916 | 0.80 | G6PD (0.50) | ALDH1A1MAPTGAAG6PDIDE | |
| SCHEMBL3398803 | 0.80 | ALDH1A1 (0.56) | ALDH1A1G6PDIDEALDH3A1LRRK2 | |
| SCHEMBL13374030 | 0.80 | GLA (0.49) | ALDH1A1MAPTGAALMNACA1 | |
| SCHEMBL11312537 | 0.76 | HTT (0.47) | ALDH1A1MAPTGAAKDM4ETHRB | |
| SCHEMBL1371001 | 0.76 | G6PD (0.53) | MAPTGAAKDM4EHTTG6PD | |
| SCHEMBL2019323 | 0.76 | LMNA (0.72) | ALDH1A1MAPTGAALMNAPKM | |
| SCHEMBL3997880 | 0.75 | G6PD (0.37) | ALDH1A1MAPTGAAKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |