Sugi Predict

Sugi Predict / Compounds / SCHEMBL339922

SCHEMBL339922

SCHEMBL339922

CC(=O)c1cc(Cl)ccc1[N+](=O)[O-]

nearest known ligand 0.65

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.57
▸ TSHR P16473 1/20 0.56
▸ MAPK1 P28482 1/20 0.56
▸ SMN1; SMN2 Q16637 1/20 0.55
▸ MAPT P10636 2/20 0.51
▸ KMT2A Q03164 3/20 0.50
▸ GAA P10253 1/20 0.49
▸ TDP1 Q9NUW8 1/20 0.49
▸ P2RX1 P51575 1/20 0.49
▸ MEN1 O00255 1/20 0.48
▸ PKM P14618 1/20 0.48
▸ ATM Q13315 1/20 0.48
▸ POLB P06746 1/20 0.47
▸ USP7 Q93009 1/20 0.47
▸ USP47 Q96K76 1/20 0.47
▸ PDE7A Q13946 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16956717 0.87 TSHR (0.58) ALDH1A1TSHRMAPK1SMN1; SMN2MAPT
SCHEMBL848335 0.86 HPGD (0.56) ALDH1A1TSHRMAPK1SMN1; SMN2POLB
SCHEMBL29758067 0.86 HPGD (0.56) ALDH1A1TSHRMAPK1SMN1; SMN2POLB
SCHEMBL40329 0.84 ALDH1A1 (0.59) ALDH1A1TSHRMAPK1SMN1; SMN2MAPT
SCHEMBL79163 0.84 DTYMK (0.62) ALDH1A1TSHRMAPK1SMN1; SMN2KMT2A
SCHEMBL10657784 0.82 ALDH1A1 (0.52) ALDH1A1TSHRMAPK1SMN1; SMN2MAPT
SCHEMBL16971197 0.82 ALDH1A1 (0.51) ALDH1A1TSHRMAPK1SMN1; SMN2MAPT
Hydrochloric Acid SCHEMBL1138798 0.82 DTYMK (0.60) ALDH1A1TSHRMAPK1SMN1; SMN2KMT2A
SCHEMBL6395556 0.82 ALDH1A1 (0.57) ALDH1A1TSHRMAPK1SMN1; SMN2MAPT
SCHEMBL6154642 0.82 ALDH1A1 (0.57) ALDH1A1TSHRMAPK1SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260022099-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2026-01-22 — — US disclosed
US-12371408-B2 Aryl hydrocarbon receptor agonists and uses thereof NEXYS THERAPEUTICS, INC. (US) 2025-07-29 — — US disclosed
US-12168646-B2 Aryl hydrocarbon receptor agonists and uses thereof NEXYS THERAPEUTICS, INC. (US) 2024-12-17 — — US disclosed
EP-4472953-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF Nexys Therapeutics, Inc. (US) 2024-12-11 — — EP disclosed
CN-118891251-A Aryl hydrocarbon receptor agonists and uses thereof 奈可萨斯医药有限公司 2024-11-01 — — CN disclosed
US-20240279185-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2024-08-22 — — US disclosed
US-20240208913-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2024-06-27 — — US disclosed
US-20240208913-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2024-06-27 — — US disclosed
WO-2023150197-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2023-08-10 — — WO disclosed
EP-2744330-B1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS UNIV UTAH RES FOUND (US) 2020-07-15 — — EP disclosed
WO-2006034333-A2 CONTROL OF PARASITES IN ANIMALS BY THE USE OF NOVEL TRIFLUOROMETHANESULFONANILIDE OXIME ETHER DERIVATIVES SCHERING-PLOUGH LTD. (CH) 2006-03-30 — — WO disclosed
US-20060063841-A1 Parasiticides; nematocides; crop protection SCHERING-PLOUGH LTD. (CH) 2006-03-23 — — US disclosed
EP-1322615-A2 FLUORINATED QUINOLONES AS ANTIMITOTIC AND ANTITUMOR AGENTS UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2003-07-02 — — EP disclosed
US-6569870-B1 Anticarcinogenic agents for breast and ovarian cancer THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2003-05-27 — — US disclosed
WO-2002026730-A2 FLUORINATED QUINOLONES AS ANTIMITOTIC AND ANTITUMOR AGENTS UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2002-04-04 — — WO disclosed
US-4888041-A POST EMERGENCE HERBICIDES THE DOW CHEMICAL COMPANY (US) 1989-12-19 — — US disclosed
US-4656267-A RENAL VASODILATORS, CARDIOVASCULAR AGENTS ORTHO PHARMACEUTICAL CORPORATION (US) 1987-04-07 — — US disclosed
US-4555571-A Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters ORTHO PHARMACEUTICAL CORPORATION (US) 1985-11-26 — — US disclosed
EP-0138491-A2 Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters ORTHO PHARMACEUTICAL CORPORATION (US) 1985-04-24 — — EP disclosed
US-4352942-A TREATMENT OF ISOMERIC MIXTURE OF NITRO AROMATIC KETO COMPOUNDS WITH OLEUM GULF RESEARCH & DEVELOPMENT COMPANY (US) 1982-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12371408-B2 Aryl hydrocarbon receptor agonists and uses thereof AHR, ARNT, NR1H2 ALDH1A1 602/4885TSHR 352/4885MAPK1 1330/4885
US-20260022099-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF AHR, NR1H4, CNR1 ALDH1A1 807/4885TSHR 254/4885MAPK1 1587/4885
US-20240279185-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF AHR, ARNT, NR1H2 ALDH1A1 602/4885TSHR 352/4885MAPK1 1330/4885
US-20060063841-A1 Parasiticides; nematocides; crop protection TRHDE, DDT, EPHX1 ALDH1A1 4339/4885TSHR 1334/4885MAPK1 3689/4885
US-12168646-B2 Aryl hydrocarbon receptor agonists and uses thereof AHR, ARNT, NR1H2 ALDH1A1 602/4885TSHR 352/4885MAPK1 1330/4885
US-20240208913-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF AHR, ARNT, NR1H2 ALDH1A1 602/4885TSHR 352/4885MAPK1 1330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.