Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10722931 | 0.68 | DRD2 (0.55) | MAPTKDM4EALDH1A1CHRM5CHRM1 | |
| SCHEMBL10823922 | 0.65 | ALDH1A1 (0.41) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL10439090 | 0.65 | KDM4E (0.51) | MAPTKDM4EALDH1A1GAATSHR | |
| SCHEMBL3325678 | 0.62 | ALDH1A1 (0.74) | KDM4EALDH1A1HPGDGAATSHR | |
| SCHEMBL8115164 | 0.58 | GAA (0.63) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL317670 | 0.57 | TSHR (0.47) | KDM4EALDH1A1HPGDTSHRCHRM5 | |
| SCHEMBL29389335 | 0.57 | TSHR (1.00) | KDM4EALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL186285 | 0.57 | TSHR (1.00) | KDM4EALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL3265630 | 0.56 | MAPT (0.64) | MAPTKDM4EALDH1A1HPGDGAA | |
| 1,2-Dimethoxybenzene SCHEMBL10829425 | 0.56 | CA1 (0.72) | ALDH1A1TSHRSMN1; SMN2HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249818-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND METHODS OF USE | Stanford University (US) | 2010-11-17 | — | — | EP | disclosed |